Sander Jansen
Katholieke Universiteit Leuven
19 Papers
13 Citations
Sander Jansen is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 14 publications. Previous affiliations of Sander Jansen include Global Virus Network.
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Papers
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages.
Els Wauters,Pierre Van Mol,Abhishek D. Garg,Sander Jansen,Yannick Van Herck,Lore Vanderbeke,Ayse Bassez,Bram Boeckx,Bert Malengier-Devlies,Anna Timmerman,Thomas Van Brussel,Tina Van Buyten,Rogier Schepers,Elisabeth Heylen,Dieter Dauwe,Christophe Dooms,Jan Gunst,Greet Hermans,Philippe Meersseman,Dries Testelmans,Jonas Yserbyt,Sabine Tejpar,Walter De Wever,Patrick Matthys,Johan Neyts,Joost Wauters,Junbin Qian,Diether Lambrechts +27 more
TL;DR: In this article, the authors used pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them and found that in mild COVID-19, CD8+ resident-memory (TRM) and CD4+ T-helper-17 (TH17) cells undergo active expansion towards the end of the trajectory, and are characterized by good effector functions, while in critical COVID19 they remain more naive.
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Robbert Boudewijns,Robbert Boudewijns,Hendrik Jan Thibaut,Hendrik Jan Thibaut,Suzanne J.F. Kaptein,Suzanne J.F. Kaptein,Rong Li,Valentijn Vergote,Laura Seldeslachts,Johan Van Weyenbergh,Carolien De Keyzer,Carolien De Keyzer,Lindsey Bervoets,Lindsey Bervoets,Sapna Sharma,Sapna Sharma,Laurens Liesenborghs,Laurens Liesenborghs,Ji Ma,Ji Ma,Sander Jansen,Sander Jansen,Dominique Van Looveren,Dominique Van Looveren,Thomas Vercruysse,Thomas Vercruysse,Xinyu Wang,Xinyu Wang,Dirk Jochmans,Dirk Jochmans,Erik Martens,Kenny Roose,Dorien De Vlieger,Bert Schepens,Tina Van Buyten,Tina Van Buyten,Sofie Jacobs,Sofie Jacobs,Yanan Liu,Joan Martí-Carreras,Bert Vanmechelen,Tony Wawina-Bokalanga,Leen Delang,Leen Delang,Joana Rocha-Pereira,Joana Rocha-Pereira,Lotte Coelmont,Lotte Coelmont,Winston Chiu,Winston Chiu,Pieter Leyssen,Pieter Leyssen,Elisabeth Heylen,Elisabeth Heylen,Dominique Schols,Lanjiao Wang,Lanjiao Wang,Lila Close,Jelle Matthijnssens,Marc Van Ranst,Veerle Compernolle,Georg Schramm,Koen Van Laere,Xavier Saelens,Nico Callewaert,Ghislain Opdenakker,Piet Maes,Birgit Weynand,Christopher Cawthorne,Greetje Vande Velde,Zhongde Wang,Johan Neyts,Johan Neyts,Kai Dallmeier,Kai Dallmeier +74 more
TL;DR: The results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients.
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Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2.
Jim Baggen,Leentje Persoons,Els Vanstreels,Sander Jansen,Dominique Van Looveren,Bram Boeckx,Vincent Geudens,Julie De Man,Dirk Jochmans,Joost Wauters,Els Wauters,Bart M. Vanaudenaerde,Diether Lambrechts,Johan Neyts,Kai Dallmeier,Hendrik Jan Thibaut,Maarten Jacquemyn,Piet Maes,Dirk Daelemans +18 more
TL;DR: It is discovered that SARS-CoV-2 requires the lysosomal protein TMEM106B to infect human cell lines and primary lung cells, and single-cell RNA-sequencing of airway cells from patients with COVID-19 demonstrated that TMEM 106B expression correlates with Sars-Cov-2 infection.
Discriminating Mild from Critical COVID-19 by Innate and Adaptive Immune Single-cell Profiling of Bronchoalveolar Lavages
Els Wauters,Pierre Van Mol,Abhishek D. Garg,Sander Jansen,Yannick Van Herck,Lore Vanderbeke,Ayse Bassez,Bram Boeckx,Bert Malengier-Devlies,Anna Timmerman,Thomas Van Brussel,Tina Van Buyten,Rogier Schepers,Elisabeth Heylen,Dieter Dauwe,Christophe Dooms,Jan Gunst,Greet Hermans,Philippe Meersseman,Dries Testelmans,Jonas Yserbyt,Patrick Matthys,Sabine Tejpar,Johan Neyts,Joost Wauters,Junbin Qian,Junbin Qian,Diether Lambrechts +27 more
TL;DR: Single-cell profiling to bronchoalveolar lavages from 44 patients with mild or critical CO VID-19 versus non-COVID-19 pneumonia as control represents a major resource for understanding the lung-localised immunity and inflammation landscape during COVID- 19.
Cellular host factors for SARS-CoV-2 infection.
TL;DR: In this article, the authors summarized insights into the proviral host factors that are required for SARS-CoV-2 infection that were mainly obtained using functional genetic and interactome screens.