Salima Janmohamed
University of Toronto
9 Papers
5 Citations
Salima Janmohamed is an academic researcher from University of Toronto. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Salima Janmohamed include Ontario Institute for Cancer Research.
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Papers
Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism
Noam Levaot,Oleksandr Voytyuk,Ioannis D. Dimitriou,Fabrice Sircoulomb,Arun A. Chandrakumar,Marcel Deckert,Paul M. Krzyzanowski,Andrew Scotter,Shengqing Gu,Salima Janmohamed,Feng Cong,Paul D. Simoncic,Yasuyoshi Ueki,Jose La Rose,Robert Rottapel,Robert Rottapel +15 more
TL;DR: It is shown that Tankyrase, a member of the poly(ADP-ribose)polymerase (PARP) family, regulates 3BP2 stability through ADp-ribosylation and subsequent ubiquitylation by the E3-ubiquitin ligase RNF146 in osteoclasts.
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3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions.
Noam Levaot,Paul D. Simoncic,Ioannis D. Dimitriou,Andrew Scotter,Jose La Rose,Adeline H.M. Ng,Thomas L. Willett,Chiachien J. Wang,Salima Janmohamed,Marc D. Grynpas,Ernst J Reichenberger,Robert Rottapel +11 more
TL;DR: An unanticipated role for the 3BP2 adapter protein in osteoblast function and in coordinating bone homeostatic signals in both osteoclast and osteobasts lineages is revealed.
Hoxa9 Transduction Induces Hematopoietic Stem and Progenitor Cell Activity through Direct Down-Regulation of Geminin Protein
Yoshinori Ohno,Shin'ichiro Yasunaga,Salima Janmohamed,Motoaki Ohtsubo,Motoaki Ohtsubo,Keita Saeki,Toshiaki Kurogi,Keichiro Mihara,Norman N. Iscove,Yoshihiro Takihara +9 more
TL;DR: The findings suggest that Hoxa 9 and Hoxb4 differ from Hoxc13 and Nup98-Hoxa9 in their molecular role in hematopoiesis, and that H Roxa9 induces the activity of HSCs and hematOPoietic progenitors at least in part through direct down-regulation of Geminin.
Identification of gene 3′ ends by automated EST cluster analysis
Enrique M. Muro,Robert Herrington,Salima Janmohamed,Catherine Frelin,Miguel A. Andrade-Navarro,Norman N. Iscove +5 more
TL;DR: It is shown that 22–52% of sequences in commonly used human and murine “full-length” transcript databases may not currently end at bona fide polyadenylation sites.
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Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats
Cindy Fishman,Jessica Caverly Rae,L. M. Posobiec,Susan B. Laffan,Steven Lerman,Neil D. Pearson,Salima Janmohamed,Etienne Dumont,Deatra Nunn-Floyd,Dinesh Stanislaus +9 more
TL;DR: The absence of treatment-related clinical signs and arthropathy in juvenile rats provides evidence to support the potential future use of gepotidacin in children.
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