Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease.

We examined the effect of the e4 allele of ApolipoproteinE (APOE) in non-demented healthy individuals in the age range of 35-85 years of age. In a prospective cohort study we demonstrated a more pr ...

The influence of APOE status on episodic and semantic memory: data from a population-based study.

Increased caveolin-1 expression in Alzheimer's disease brain.

Objective: To examine the relationship between cholesterol and other lipids, APOE genotype, and risk of Alzheimer disease (AD) in a population-based study of elderly Yoruba living in Ibadan, Nigeria. Methods: Blood samples and clinical data were collected from Yoruba study participants aged 70 years and older (N = 1,075) as part of the Indianapolis-Ibadan Dementia Project, a longitudinal epidemiologic study of AD. Cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride levels were measured in fasting blood samples. DNA was extracted and APOE was genotyped. Diagnoses of AD were made by consensus using National Institute of Neurologic Disorders/Stroke-Alzheimer9s Disease and Related Disorders Association criteria. Results: Logistic regression models showed interaction after adjusting for age and gender between APOE -e4 genotype and biomarkers in the risk of AD cholesterol*genotype ( p = 0.022), LDL*genotype ( p = 0.018), and triglyceride*genotype ( p = 0.036). Increasing levels of cholesterol and LDL were associated with increased risk of AD in individuals without the APOE -e4 allele, but not in those with APOE -e4. There was no significant association between levels of triglycerides and AD risk in those without APOE -e4. Conclusions: There was a significant interaction between cholesterol, APOE -e4, and the risk of Alzheimer disease (AD) in the Yoruba, a population that has lower cholesterol levels and lower incidence rates of AD compared to African Americans. APOE status needs to be considered when assessing the relationship between lipid levels and AD risk in population studies.

Cholesterol, APOE genotype, and Alzheimer disease An epidemiologic study of Nigerian Yoruba

Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis

Background: Human apolipoprotein (Apo) E4 (ApoE4) is an important determinant of lipid metabolism and cell-to-cell cholesterol transport. It is also a major genetic risk factor for

The relationship between apolipoprotein E4 and lipid metabolism is impaired in Alzheimer's disease.

Les maladies cardiovasculaires constituent la plus importante cause de mortalite chez les insuffisants renaux chroniques traites par hemodialyse. Dans cette population, les perturbations lipidiques et l'existence d'un stress oxydant sont parmi les facteurs de risque actuellement reconnus qui pourraient permettre une prevention primaire. Avant d'envisager les moyens therapeutiques, nous avons analyse les perturbations du metabolisme oxydatif chez le patient hemodialyse (production d'especes reactives de l'oxygene (ROS), mecanismes de defense, equilibre monoxyde d'azote (NO) and ROS. Au cours des seances de dialyse realisees avec membrane cellulosique (Cuprophane), nous avons observe une production accrue d'hyperoxydes par les plaquettes (12 HETE) (5,62 ± 0,94 pg) et d'anion superoxyde (O 0 2 ) par les monocytes (index de fluorescence 115 ± 24) et les polynucleaires (index de fluorescence 115 ± 24). Par ailleurs, les systemes de defense antiradicalaire sont profondement alteres: baisse de l'activite SOD globulaire (0,92 ± 0,06 U/mg Hg) et de la vitamine E erythrocytaire (0,7 ± 0,07 mg/l de culot). Alors que les proprietes anti- ou pro-oxydantes du NO semblent liees a l'equilibre NO/ROS, nous avons mis en evidence une alteration du metabolisme du NO secondaire a une accumulation d'inhibiteurs ou au contraire d'activateurs des NO synthases. L'utilisation des membranes biocompatibles (cuprophane passive ou membranes synthetiques: polysulfone) qui diminuent l'activation des leucocytes circulants reduit la production de ROS. Les inhibiteurs des NOS peuvent etre elimines preferentiellement par convection. Enfin une supplementation en anti-oxydant exogene (vitamine E per os, 500 mg/j pendant 6 mois) permet de corriger le deficit en vitamine E erythrocytaire et de diminuer les taux plasmatiques de MDA. Les perturbations du metabolisme oxydatif en hemodialyse sont multifactorielles; leur prevention doit etre envisagee a plusieurs niveaux: amelioration de la biocompatibilite du materiel de dialyse, restauration de la balance NO/ROS et enfin supplementation en anti-oxydants.

[Oxidative stress and chronic renal insufficiency: what can be a prophylactic approach?].

Popular Tasks used by Researchers

How can I help with your research?

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

We encountered an error while loading the panel. Please try refreshing the page.

Something went wrong

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

Anyone with the link can view this chat. You can switch it back to private anytime.

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

S. Badiou

Author Tools

Chat about Author

Papers

The relationship between apolipoprotein E4 and lipid metabolism is impaired in Alzheimer's disease.

[Oxidative stress and chronic renal insufficiency: what can be a prophylactic approach?].