Ryuta Nishikomori
Kurume University
200 Papers
860 Citations
Ryuta Nishikomori is an academic researcher from Kurume University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 37, co-authored 165 publications. Previous affiliations of Ryuta Nishikomori include Hiroshima University & Central Institute for Experimental Animals.
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Papers
Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation: common genetic etiology with Blau syndrome
Nobuo Kanazawa,Ikuo Okafuji,Naotomo Kambe,Ryuta Nishikomori,Mami Nakata-Hizume,Sonoko Nagai,Akihiko Fuji,Takenosuke Yuasa,Akira Manki,Yoshihiko Sakurai,Mitsuru Nakajima,Hiroko Kobayashi,Ikuma Fujiwara,Hiroyuki Tsutsumi,Atsushi Utani,Chikako Nishigori,Toshio Heike,Tatsutoshi Nakahata,Yoshiki Miyachi +18 more
TL;DR: Findings indicate that the majority of EOS and BS cases share the common genetic etiology of CARD15 mutations that cause constitutive NF-kappaB activation.
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High Incidence of NLRP3 Somatic Mosaicism in Patients With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome: Results of an International Multicenter Collaborative Study
Naoko Tanaka,Kazushi Izawa,Megumu K. Saito,Mio Sakuma,Koichi Oshima,Osamu Ohara,Ryuta Nishikomori,Takeshi Morimoto,Naotomo Kambe,Raphaela Goldbach-Mansky,Ivona Aksentijevich,Geneviève de Saint Basile,Bénédicte Neven,Marielle E. van Gijn,Joost Frenkel,Juan I. Aróstegui,Jordi Yagüe,Rosa Merino,Mercedes Ibañez,Alessandra Pontillo,Hidetoshi Takada,Tomoyuki Imagawa,Tomoki Kawai,Takahiro Yasumi,Tatsutoshi Nakahata,Toshio Heike +25 more
TL;DR: Somatic NLRP3 mosaicism is a major cause of NOMID/CINCA syndrome, and in vitro functional assays indicated that the detected somaticNLRP3 mutations had disease-causing functional effects.
BCG vaccination in patients with severe combined immunodeficiency: Complications, risks, and vaccination policies
Beatriz E. Marciano,Chiung Yu Huang,Gyan Joshi,Nima Rezaei,Beatriz Tavares Costa Carvalho,Z. Allwood,Aydan Ikinciogullari,Shereen M. Reda,Andrew R. Gennery,Vojtech Thon,Francisco J. Espinosa-Rosales,Waleed Al-Herz,Oscar Porras,Anna Shcherbina,Anna Szaflarska,S. Kiliç,José Luis Franco,Andrea C. Gómez Raccio,Pérsio Roxo,I. Esteves,Nermeen Galal,Anete Sevciovic Grumach,Salem Al-Tamemi,Alisan Yildiran,Julio Orellana,Masafumi Yamada,Tomohiro Morio,Diana Liberatore,Yoshitoshi Ohtsuka,Yu-Lung Lau,Ryuta Nishikomori,Carlos Torres-Lozano,Juliana Themudo Lessa Mazzucchelli,Maria Marluce dos Santos Vilela,Fabiola Scancetti Tavares,Luciana Cristina Matos Cunha,Jorge Pinto,Sara Elva Espinosa-Padilla,Leticia Hernandez-Nieto,Reem Elfeky,Tadashi Ariga,Heike Toshio,Figen Dogu,Funda Erol Cipe,Renata Formankova,M. Enriqueta Nuñez-Nuñez,Liliana Bezrodnik,Jose Gonçalo Marques,María I. Pereira,Viviana Listello,Mary Slatter,Zohreh Nademi,Danuta Kowalczyk,Thomas A. Fleisher,Graham Davies,Bénédicte Neven,Sergio D. Rosenzweig +56 more
TL;DR: Until safer and more efficient antituberculosis vaccines become available, delay in BCG vaccination should be considered to protect highly vulnerable populations from preventable complications.
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Aicardi-Goutières syndrome is caused by IFIH1 mutations.
Hirotsugu Oda,Kenji Nakagawa,Junya Abe,Tomonari Awaya,Masahide Funabiki,Atsushi Hijikata,Ryuta Nishikomori,Makoto Funatsuka,Yusei Ohshima,Yuji Sugawara,Takahiro Yasumi,Hiroki Kato,Tsuyoshi Shirai,Osamu Ohara,Takashi Fujita,Toshio Heike +15 more
TL;DR: This study suggests that the IFIH1 mutations are responsible for the AGS phenotype due to an excessive production of type I interferon.
Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
Yuumi Nakamura,Naotomo Kambe,Megumu K. Saito,Ryuta Nishikomori,Yun Gi Kim,Makoto Murakami,Gabriel Núñez,Hiroyuki Matsue +7 more
TL;DR: These findings implicate mast cells (MCs) as IL-1β producers in the skin and mediators of histamine-independent urticaria through the NLRP3 inflammasome.
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