Russell L. Marsden
University College London
17 Papers
322 Citations
Russell L. Marsden is an academic researcher from University College London. The author has contributed to research in topics: Structural genomics & Protein domain. The author has an hindex of 12, co-authored 17 publications.
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Papers
Protein structure prediction servers at University College London
Kevin Bryson,Liam J. McGuffin,Russell L. Marsden,Jonathan J. Ward,Jaspreet Singh Sodhi,David T. Jones +5 more
TL;DR: A number of state-of-the-art protein structure prediction servers have been developed by researchers working in the Bioinformatics Unit at University College London, and these servers include DISOPRED for the prediction of protein dynamic disorder and DomPred for domain boundary prediction.
The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis
Frances M. G. Pearl,Annabel E. Todd,Ian Sillitoe,Mark Dibley,Oliver C. Redfern,Tony E. Lewis,Christopher G. Bennett,Russell L. Marsden,Alastair Grant,David A. Lee,Adrian Akpor,Michael Maibaum,Andrew Harrison,Timothy J. Dallman,Gabrielle A. Reeves,Ilhem Diboun,Sarah Addou,Stefano Lise,Caroline Johnston,Antonio Sillero,Janet M. Thornton,Christine A. Orengo +21 more
TL;DR: The CATH database of protein domain structures currently contains 43 229 domains classified into 1467 superfamilies and 5107 sequence families is expanded with sequence relatives from GenBank and completed genomes, using a variety of efficient sequence search protocols and reliable thresholds.
Rapid protein domain assignment from amino acid sequence using predicted secondary structure
TL;DR: How successfully the delineation of continuous domains can be accomplished in the absence of sequence homology is addressed using simple baseline methods, an existing prediction algorithm (Domain Guess by Size), and a newly developed method (DomSSEA).
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Progress of structural genomics initiatives: an analysis of solved target structures.
TL;DR: In this article, a comprehensive analysis of solved structural genomics targets is presented to assess progress of these initiatives, and the authors conclude that the quality and size of these proteins are comparable to those solved in traditional structural biology and, despite huge scope for duplicated efforts, only 14% of targets have a close homologue (>/=30% sequence identity) solved by another consortium.
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•Journal Article
Progress of structural genomics initiatives: An analysis of solved target structures (vol 348, pg 1235, 2005)
TL;DR: A comprehensive analysis of solved SG targets appears that structural genomics is on track to be a success, and it is hoped that this work will inform future directions of the field.
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