Robert L. Sah
University of California, San Diego
310 Papers
2.5K Citations
Robert L. Sah is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cartilage & Chondrocyte. The author has an hindex of 76, co-authored 306 publications. Previous affiliations of Robert L. Sah include University of Vienna & Rush University Medical Center.
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Papers
Fluorometric assay of DNA in cartilage explants using Hoechst 33258.
TL;DR: A simple two-step fluorometric assay of DNA in cartilage explants, utilizing the bisbenzimidazole dye Hoechst 33258, is described, which offers advantages over other established DNA assays of Cartilage and may be especially useful in metabolic studies of cartilageExplants.
1.4K
Biosynthetic response of cartilage explants to dynamic compression.
TL;DR: This study provides a framework for identifying both the physical and biological mechanisms by which dynamic compression can modulate chondrocyte biosynthesis and potentially allows in vitro evaluation of clinical strategies of continuous passive motion therapy to stimulate cartilage remodeling.
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Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
Spencer C. Wei,Laurent Fattet,Jeff H. Tsai,Yurong Guo,Vincent Pai,Hannah E. Majeski,Albert C. Chen,Robert L. Sah,Susan S. Taylor,Adam J. Engler,Jing Yang +10 more
TL;DR: It is reported that TWIST1 is an essential mechanomediator that promotes epithelial–mesenchymal transition (EMT) in response to increasing matrix stiffness that responds to biomechanical signals from the tumour microenvironment to drive EMT, invasion and metastasis.
Depth-dependent confined compression modulus of full-thickness bovine articular cartilage.
TL;DR: The delineation of the depth‐dependent modulus provides a basis for detailed study of the relationship between the composition, structure, and function of cartilage in such processes as aging, repair, and degeneration.
677
Probing the role of multicellular organization in three-dimensional microenvironments
Dirk R. Albrecht,Gregory H. Underhill,Gregory H. Underhill,Travis B Wassermann,Robert L. Sah,Sangeeta N. Bhatia,Sangeeta N. Bhatia,Sangeeta N. Bhatia +7 more
TL;DR: By modulating cell-cell interactions in 3D clusters, the first evidence that microscale tissue organization regulates bovine articular chondrocyte biosynthesis is presented, and this platform permits investigation of tissue architecture in other multicellular processes.
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