
 Abstract
 
 Fusion of the viral and host cell membranes is a necessary first step for infection by enveloped viruses and is mediated by the envelope glycoprotein. The transmembrane subunits from the structurally defined “class I” glycoproteins adopt an α-helical “trimer-of-hairpins” conformation during the fusion pathway. Here, we present our studies on the envelope glycoprotein transmembrane subunit, GP2, of the CAS virus (CASV). CASV was recently identified from annulated tree boas (Corallus annulatus) with inclusion body disease and is implicated in the disease etiology. We have generated and characterized two protein constructs consisting of the predicted CASV GP2 core domain. The crystal structure of the CASV GP2 post-fusion conformation indicates a trimeric α-helical bundle that is highly similar to those of Ebola virus and Marburg virus GP2 despite CASV genome homology to arenaviruses. Denaturation studies demonstrate that the stability of CASV GP2 is pH dependent with higher stability at lower pH; we propose that this behavior is due to a network of interactions among acidic residues that would destabilize the α-helical bundle under conditions where the side chains are deprotonated. The pH-dependent stability of the post-fusion structure has been observed in Ebola virus and Marburg virus GP2, as well as other viruses that enter via the endosome. Infection experiments with CASV and the related Golden Gate virus support a mechanism of entry that requires endosomal acidification. Our results suggest that, despite being primarily arenavirus like, the transmembrane subunit of CASV is extremely similar to the filoviruses.
 


From a Novel

This contribution summarizes the use of plasmon surface polaritons and guided optical waves for the characterization of interfaces and thin organic films. After a short introduction to the theoretical background of evanescent wave optics, examples are given that show how this interfacial “light” can be employed to monitor thin coatings at a solid/air or solid/liquid interface. Examples are given for a very sensitive thickness determination of samples ranging from self-assembled monolayers, to multilayer assemblies prepared by the Langmuir/Blodgett/Kuhn technique or by the alternate polyelectrolyte deposition. These are complemented by the demonstration of the potential of the technique to also monitor time-dependent processes in a kinetic mode. Here, we put an emphasis on the combination set-up of surface plasmon optics with electrochemical techniques, allowing for the online characterization of various surface functionalization strategies, e.g. for (bio-) sensor purposes.

/pdf/interfaces-and-thin-films-as-seen-by-bound-electromagnetic-1h2g3yn73y.pdf

Interfaces and thin films as seen by bound electromagnetic waves

In order to enable optical systems to operate with a high degree of compactness and reliability it is necessary to combine large number of optical functions in small monolithic structures. A development, somewhat reminiscent of that that took place in Integrated Electronics, is now beginning to take place in optics. The initial challenge in this emerging field, known appropriately as "Integrated Optics", is to demonstrate the possibility of performing basic optical functions such as light generation, coupling, modulation, and guiding in Integrated Optical configurations. The talk will review the main theoretical and experimental developments to date in Integrated Optics. Specific topics to be discussed include: Material considerations, guiding mechanisms, modulation, coupling and mode losses. The fabrication and applications of periodic thin film structures will be discussed.

Integrated optics

We review the family of optoelectronic devices whose performance is enhanced by placing the active device structure inside a Fabry‐Perot resonantmicrocavity. Such resonantcavity enhanced (RCE) devices benefit from the wavelength selectivity and the large increase of the resonant optical field introduced by the cavity. The increased optical field allows RCE photodetector structures to be thinner and therefore faster, while simultaneously increasing the quantum efficiency at the resonant wavelengths. Off‐resonance wavelengths are rejected by the cavity making RCE photodetectors promising for low crosstalk wavelength division multiplexing(WDM) applications. RCE optical modulators require fewer quantum wells so are capable of reduced voltage operation. The spontaneous emission spectrum of RCE light emitting diodes(LED) is drastically altered, improving the spectral purity and directivity. RCE devices are also highly suitable for integrated detectors and emitters with applications as in optical logic and in communication networks. This review attempts an encyclopedic overview of RCE photonicdevices and systems. Considerable attention is devoted to the theoretical formulation and calculation of important RCE device parameters. Materials criteria are outlined and the suitability of common heteroepitaxial systems for RCE devices is examined. Arguments for the improved bandwidth in RCE detectors are presented intuitively, and results from advanced numerical simulations confirming the simple model are provided. An overview of experimental results on discrete RCE photodiodes, phototransistors, modulators, and LEDs is given. Work aimed at integrated RCE devices,optical logic and WDM systems is also covered. We conclude by speculating what remains to be accomplished to implement a practical RCE WDM system.

Resonant cavity enhanced photonic devices

Ultraviolet (UV) photodetection has drawn a great deal of attention in recent years due to a wide range of civil and military applications. Because of its wide band gap, low cost, strong radiation hardness and high chemical stability, ZnO are regarded as one of the most promising candidates for UV photodetectors. Additionally, doping in ZnO with Mg elements can adjust the bandgap largely and make it feasible to prepare UV photodetectors with different cut-off wavelengths. ZnO-based photoconductors, Schottky photodiodes, metal–semiconductor–metal photodiodes and p–n junction photodetectors have been developed. In this work, it mainly focuses on the ZnO and ZnMgO films photodetectors. We analyze the performance of ZnO-based photodetectors, discussing recent achievements, and comparing the characteristics of the various photodetector structures developed to date.

https://www.mdpi.com/1424-8220/10/9/8604/pdf

ZnO-Based Ultraviolet Photodetectors

Integrated Optics explains the subject of optoelectronic devices and their use in integrated optics and fiber optic systems The approach taken is to emphasize the physics of how devices work and how they can be (and have been) used in various applications as the field of optoelectronics has progressed from microphotonics to nanophotonics Illustrations and references from technical journals have been used to demonstrate the relevance of the theory to currently important topics in industry By reading this book, scientists, engineers, students and engineering managers can obtain an overall view of the theory and the most recent technology in Integrated Optics

/pdf/integrated-optics-theory-and-technology-4ocdozkztn.pdf

Integrated optics, theory and technology

Integrated Optics explains the subject of optoelectronic devices and their use in integrated optics and fiber optic systems. The approach taken is to emphasize the physics of how devices work and how they can be (and have been) used in various applications as the field of optoelectronics has progressed from microphotonics to nanophotonics. Illustrations and references from technical journals have been used to demonstrate the relevance of the theory to currently important topics in industry. By reading this book, scientists, engineers, students and engineering managers can obtain an overall view of the theory and the most recent technology in Integrated Optics.

Integrated optics: Theory and technology

Integrated optics : theory and technology

A wavelength division method and system employing a radiation transmissive planar waveguide provided with collimating and focusing lenses and with a periodic radiation transmissive diffraction grating incorporating radiation reflecting elements in spaced array, preselected, in demultiplexing service, to separate into individual entities an optical signal input constituting a multiplicity of coherent radiation signals of different characteristic wavelengths transmitted simultaneously via the waveguide and, in multiplexing service, to consolidate a multiplicity of coherent radiation signals individually introduced to the grating via the waveguide along angular courses substantially coincident with the angular courses taken by individual radiation signals of corresponding wavelengths exiting the grating during demultiplexing service, and means directing the signals to dedicated receptors.

Optical wavelength division multiplexing/demultiplexing system

Single-mode distributed feedback (DFB) laser diodes typically require a two-step epitaxial growth or use of a corrugated substrate. We demonstrate InGaAs-GaAs-AlGaAs DFB lasers fabricated from a single epitaxial growth using lateral evanescent coupling of the optical field to a surface grating etched along the sides of the ridge. A CW threshold current of 25 mA and external quantum efficiency of 0.48 mW/mA per facet were measured for a 1 mm cavity length device with anti-reflection coated facets. Single-mode output powers as high as 11 mW per facet at 935 nm wavelength were attained. A coupling coefficient of at least 5.8 cm/sup -1/ was calculated from the subthreshold spectrum taking into account the 2% residual facet reflectivity. >

/pdf/cw-performance-of-an-ingaas-gaas-algaas-laterally-coupled-1q8cwd8tms.pdf

CW performance of an InGaAs-GaAs-AlGaAs laterally-coupled distributed feedback (LC-DFB) ridge laser diode

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