Robert B. Warner
University of South Florida
9 Papers
107 Citations
Robert B. Warner is an academic researcher from University of South Florida. The author has contributed to research in topics: Farnesyltransferase & Chemistry. The author has an hindex of 9, co-authored 9 publications.
Chat about Author
Papers
Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation
Le Wang,Keith W. Woods,Qun Li,Kenneth J. Barr,Mccroskey Richard W,Steven M. Hannick,Laura Gherke,R. Bruce Credo,Yu Hua Hui,Kennan C. Marsh,Robert B. Warner,Jang Y. Lee,Nicolette Zielinski-Mozng,David Frost,Saul H. Rosenberg,Hing L. Sham +15 more
TL;DR: 4,5-Disubstituted imidazole was found to be the best for the replacement of the cis double bond in CA-4 and Medicinal chemistry efforts led to the discovery of compounds 24h and 25f that were finding to be 32 and 82% bioavailable, respectively, in rat.
465
Influence of Bcl-2 Family Members on the Cellular Response of Small-Cell Lung Cancer Cell Lines to ABT-737
Stephen K. Tahir,Xiufen Yang,Mark G. Anderson,Susan Morgan-Lappe,Aparna Sarthy,Jun Chen,Robert B. Warner,Shi-Chung Ng,Stephen W. Fesik,Steve W. Elmore,Saul H. Rosenberg,Christin Tse +11 more
TL;DR: Observations provide further insight as to the mechanistic bases for ABT-737 efficacy in SCLC and will be helpful for profiling patients and aiding in the rational design of combination therapies.
335
A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs In vitro and In vivo
Alex R. Shoemaker,Anatol Oleksijew,Joy Bauch,Barbara A. Belli,Tony Borre,Milan Bruncko,Thomas Deckwirth,David Frost,Ken Jarvis,Mary K. Joseph,Kennan C. Marsh,Mcclellan William J,Hugh N. Nellans,Shi-Chung Ng,Paul Nimmer,Jacqueline M. O'Connor,Tilman Oltersdorf,Weiguo Qing,Wang Shen,Jason Stavropoulos,Stephen K. Tahir,Baole Wang,Robert B. Warner,Haichao Zhang,Stephen W. Fesik,Saul H. Rosenberg,Steven W. Elmore +26 more
TL;DR: A-385358 enhances the in vitro cytotoxic activity of numerous chemotherapeutic agents (pac litaxel, etoposide, cisplatin, and doxorubicin) in several tumor cell lines and potentiates the activity of paclitaxel in vivo.
152
Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.
Qun Li,Keith W. Woods,Akiyo Claiborne,Stephen L. Gwaltney,Kenneth J. Barr,Gang Liu,Laura Gehrke,R. Bruce Credo,Yu Hua Hui,Jang Lee,Robert B. Warner,Peter Kovar,Michael A. Nukkala,Nicolette A. Zielinski,Stephen K. Tahir,Michael C. Fitzgerald,Ki H. Kim,Kennan C. Marsh,David Frost,Shi Chung Ng,Saul H. Rosenberg,Hing L. Sham +21 more
TL;DR: A series of indole containing oxazolines has been discovered as a result of structural modifications of the lead compound A-105972, and A-289099 was identified as an orally active antimitotic agent active against various cancer cell lines including those that express the MDR phenotype.
124
Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents
Stephen L. Gwaltney,Hovis M. Imade,Kenneth J. Barr,Qun Li,Laura Gehrke,R. Bruce Credo,Robert B. Warner,Jang Yun Lee,Peter Kovar,Jieyi Wang,Michael A. Nukkala,Nicolette A. Zielinski,David Frost,Shi Chung Ng,Hing L. Vernon Hills Sham +14 more
TL;DR: Sulfonate analogues of combretastatin A-4 have been prepared as mentioned in this paper, which are potent inhibitors of tubulin polymerization and cell proliferation and also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
58