26 Papers
195 Citations
Rob Tierney is an academic researcher from National Institute for Biological Standards and Control. The author has contributed to research in topics: Toxoid & Tetanus. The author has an hindex of 12, co-authored 24 publications.
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Papers
Detection of Antibodies Against Botulinum Toxins
TL;DR: Alternative approaches for the detection of antibodies to botulinum toxin have included in vitro endopeptidase activity neutralisation, and unlike any other functional assay, this approach is not reliant on serotype‐specific antibodies for specificity.
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Transcutaneous Immunization with Tetanus Toxoid and Mutants of Escherichia coli Heat-Labile Enterotoxin as Adjuvants Elicits Strong Protective Antibody Responses
Rob Tierney,Anne-Sophie Beignon,Rino Rappuoli,Sylviane Muller,Dorothea Sesardic,Charalambos D. Partidos +5 more
TL;DR: It is demonstrated that mutants of enterotoxins with reduced toxicity are effective adjuvants for transcutaneous immunization.
Development and use of a novel in vitro assay for testing of diphtheria toxoid in combination vaccines.
TL;DR: A simple and sensitive Enzyme Linked Immunosorbent Assay (ELISA) is described which has been developed to quantify diphtheria toxoid antigen in combined vaccine products and can also be used to monitor the degree of adsorption.
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Development of human-like scFv-Fc antibodies neutralizing Botulinum toxin serotype B.
Christine Rasetti-Escargueil,Arnaud Avril,Siham Chahboun,Rob Tierney,Nicola Bak,Sebastian Miethe,Christelle Mazuet,Michel R. Popoff,Philippe Thullier,Michael Hust,Thibaut Pelat,Dorothea Sesardic +11 more
TL;DR: In this paper, macaques were immunized with recombinant light chain (LC) or heavy chain (HC) of BoNT/B2, followed by the construction of two hyper-immune phage display libraries.
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A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice
Rob Tierney,Toru Nakai,Toru Nakai,Christopher J. Parkins,Patrizia Caposio,Neil F. Fairweather,Dorothea Sesardic,Michael A. Jarvis +7 more
TL;DR: The ability of a 'single-dose' CMV-based vaccine strategy to induce durable protection in mice is demonstrated, and the potential for a tetanus vaccine based on CMV to impact the incidence of tetanus in developing countries is supported.
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