Rob Klaassen
3 Papers
35 Citations
Rob Klaassen is an academic researcher. The author has contributed to research in topics: Pharmacokinetics & Developmental toxicity. The author has an hindex of 3, co-authored 3 publications.
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Papers
Embryotoxicity of carbamazepine in rat postimplantation embryo culture after in vitro exposure via three different routes
Aldert H. Piersma,Aart Verhoef,Antoon Opperhuizen,Rob Klaassen,Jan Van Eijkeren,Martin Olling +5 more
TL;DR: It is concluded that uptake from the culture medium via the yolk sac circulation is the relevant exposure route to be used for embryotoxicity effect assessment.
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Comparison of in vitro and in vivo Developmental Toxicity and Pharmacokinetics of Phenytoin in the Rat
TL;DR: The findings show that with similar intra-embryonic concentrations of phenytoin the embryotoxicity in rat whole embryo culture was not comparable with the in vivo embryotoxic effects as determined on gestation day 11, indicating that absorption is the limiting factor at the dose range used.
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Comparison of in vitro and in vivo Developmental Toxicity and Pharmacokinetics of Phenytoin in the Rat: PHENYTOIN EMBRYOTOXICITY AND KINETICS
TL;DR: The findings show that with similar intra-embryonic concentrations of phenytoin the embryotoxicity in rat whole embryo culture was not comparable with the in vivo embryotoxic effects as determined on gestation day 11, indicating that absorption is the limiting factor at the dose range used.
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