Raul Rabadan
Columbia University
386 Papers
2.6K Citations
Raul Rabadan is an academic researcher from Columbia University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 69, co-authored 362 publications. Previous affiliations of Raul Rabadan include Cornell University & Columbia University Medical Center.
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Papers
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
Michele Ceccarelli,Floris P. Barthel,Tathiane M. Malta,Thais S. Sabedot,Sofie R. Salama,Bradley A. Murray,Olena Morozova,Yulia Newton,Amie Radenbaugh,Stefano Maria Pagnotta,Samreen Anjum,Jiguang Wang,Ganiraju C. Manyam,Pietro Zoppoli,Shiyun Ling,Arjun A. Rao,Mia Grifford,Andrew D. Cherniack,Hailei Zhang,Laila M. Poisson,Carlos Gilberto Carlotti,Daniela Pretti da Cunha Tirapelli,Arvind Rao,Tom Mikkelsen,Ching C. Lau,W. K. Alfred Yung,Raul Rabadan,Jason T. Huse,Daniel J. Brat,Norman L. Lehman,Jill S. Barnholtz-Sloan,Siyuan Zheng,Kenneth R. Hess,Ganesh Rao,Matthew Meyerson,Rameen Beroukhim,Lee Cooper,Rehan Akbani,Margaret Wrensch,David Haussler,Kenneth Aldape,Peter W. Laird,David H. Gutmann,Houtan Noushmehr,Antonio Iavarone,Roel G.W. Verhaak +45 more
TL;DR: The complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas were defined from The Cancer Genome Atlas and molecular profiles were used to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease.
2K
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dianne H. Dapito,Ali M. Mencin,Geum-Youn Gwak,Geum-Youn Gwak,Jean-Philippe Pradere,Myoung-Kuk Jang,Ingmar Mederacke,Jorge Matias Caviglia,Hossein Khiabanian,Adebowale Adeyemi,Ramon Bataller,Jay H. Lefkowitch,Maureen A. Bower,Richard A. Friedman,R. Balfour Sartor,Raul Rabadan,Robert F. Schwabe +16 more
TL;DR: Gut sterilization restricted to late stages of hepatocarcinogenesis reduced HCC, suggesting that the intestinal microbiota and TLR4 represent therapeutic targets for HCC prevention in advanced liver disease.
1.2K
Analysis of the coding genome of diffuse large B-cell lymphoma
Laura Pasqualucci,Vladimir Trifonov,Giulia Fabbri,Jing Ma,Davide Rossi,Annalisa Chiarenza,Victoria A. Wells,Adina Grunn,Monica Messina,Oliver Elliot,Joseph M. Chan,Govind Bhagat,Amy Chadburn,Gianluca Gaidano,Charles G. Mullighan,Raul Rabadan,Riccardo Dalla-Favera +16 more
TL;DR: By combining next-generation sequencing and copy number analysis, it is shown that the DLBCL coding genome contains, on average, more than 30 clonally represented gene alterations per case and novel dysregulated pathways underlying its pathogenesis are identified.
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
Laura Pasqualucci,David Dominguez-Sola,Annalisa Chiarenza,Giulia Fabbri,Adina Grunn,Vladimir Trifonov,Lawryn H. Kasper,Stephanie Lerach,Hongyan Tang,Jing Ma,Davide Rossi,Amy Chadburn,Vundavalli V. Murty,Charles G. Mullighan,Gianluca Gaidano,Raul Rabadan,Paul K. Brindle,Riccardo Dalla-Favera +17 more
TL;DR: The results identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell non-Hodgkin’s lymphoma, with direct implications for the use of drugs targeting acetylation/deacetylation mechanisms.
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.
Junfei Zhao,Andrew X. Chen,Robyn D. Gartrell,Andrew M. Silverman,Luis Aparicio,Tim Chu,Darius Bordbar,David Shan,Jorge Samanamud,Aayushi Mahajan,Ioan Filip,Rose Orenbuch,Morgan Goetz,Jonathan T. Yamaguchi,Michael Cloney,Craig Horbinski,Rimas V. Lukas,Jeffrey Raizer,Ali I Rae,Jinzhou Yuan,Peter Canoll,Jeffrey N. Bruce,Yvonne M. Saenger,Peter A. Sims,Fabio M. Iwamoto,Adam M. Sonabend,Raul Rabadan +26 more
TL;DR: This study shows that clinical response to anti-PD-1 immunotherapy in GBM is associated with specific molecular alterations, immune expression signatures, and immune infiltration that reflect the tumor’s clonal evolution during treatment.
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