Rasmus Iversen
Oslo University Hospital
40 Papers
45 Citations
Rasmus Iversen is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Tissue transglutaminase & Epitope. The author has an hindex of 15, co-authored 23 publications. Previous affiliations of Rasmus Iversen include University of Oslo.
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Papers
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
Roberto Di Niro,Luka Mesin,Nai-Ying Zheng,Jorunn Stamnaes,Michael Morrissey,Jane-Hwei Lee,Min Huang,Rasmus Iversen,M. Fleur du Pré,Shuo-Wang Qiao,Knut E.A. Lundin,Patrick C. Wilson,Ludvig M. Sollid +12 more
TL;DR: It is found that TG2-specific plasma cells are markedly expanded within the duodenal mucosa in individuals with active celiac disease, demonstrating that there is a germline repertoire with high affinity for TG2 that may favor massive generation of autoreactive B cells.
210
The Immunobiology and Pathogenesis of Celiac Disease.
Rasmus Iversen,Ludvig M. Sollid +1 more
TL;DR: Current understanding of the immunobiology of celiac disease is presented, with mechanistic insights into how the disease-predisposing HLA-DQ molecules, via presentation of posttranslationally modified gluten peptides, are connected to the generation of these autoantibodies.
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Transglutaminase 2–Specific Autoantibodies in Celiac Disease Target Clustered, N-Terminal Epitopes Not Displayed on the Surface of Cells
Rasmus Iversen,Roberto Di Niro,Jorunn Stamnaes,Knut E.A. Lundin,Patric C. Wilson,Ludvig M. Sollid +5 more
TL;DR: It is proposed that the autoantibodies are generated against the soluble, catalytically active enzyme, whereas Abs reactive with cell surface–associated TG2 are absent from the response due to negative selection of B cells recognizing membrane-bound self-Ag.
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease.
Lene Støkken Høydahl,Lene Støkken Høydahl,Lisa Richter,Rahel Frick,Rahel Frick,Omri Snir,Kristin Støen Gunnarsen,Kristin Støen Gunnarsen,Ole J. B. Landsverk,Rasmus Iversen,Jeliazko R. Jeliazkov,Jeffrey J. Gray,Elin Bergseng,Stian Foss,Stian Foss,Shuo-Wang Qiao,Shuo-Wang Qiao,Knut E.A. Lundin,Jørgen Jahnsen,Jørgen Jahnsen,Frode L. Jahnsen,Inger Sandlie,Inger Sandlie,Ludvig M. Sollid,Ludvig M. Sollid,Geir Åge Løset,Geir Åge Løset +26 more
TL;DR: Results indicate that plasma cells in the gut can function as antigen-presenting cells and might promote and maintain intestinal inflammation in patients with celiac disease or other inflammatory disorders.
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The adaptive immune response in celiac disease
TL;DR: Recent developments in the understanding of the role of T cells, B cells, and antigen-presenting cells in the pathogenic immune response of this instructive disorder are reviewed.
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