A system and method for prosthesis fitting in joints comprising an artificial condyle (32) and a spacer (34) which cooperates with the condyle (32) to form an artificial joint (30). The spacer (34) embedded with at least one sensor (35) which is responsive to a force generated between the condyle (32) and the spacer (34). The artificial joint (30) is adapted to move between a flexed position and an extended position defining a range of motion. The sensor (35) is responsive to the force and generates an output representative of that force. The output is transmitted, either wirelessly or other, to a processor which utilizes an analysis program (40)to display (24) a representation of the forces applied. A practioner utilizing the displayed analysis (24) may intraoperatively determine the adjustments and balancing required within the a rtificial joint (30). The system may also utilize a ligament tension sensor (38) which generates data representative of tension on a ligament of the artificial joint, and a joint angle sensor (36) responsive to the range of motion of the artificial joint. The processor (14) may be adapted to store the outputted sensor data to provide the practioner with statistically relevant historical data.

System and method for prosthetic fitting and balancing in joints

This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication.

Methods for generating high titer helper-free preparations of released recombinant AAV vectors

A device for performing a surgical procedure on a knee includes an adjustable femoral portion, a tibial portion and at least one sensor coupled with the femoral and/or tibial portions to sense pressure exerted by the femoral and tibial portions against one another. The femoral portion is adapted for removably coupling with a distal end of a femur to adjust tension in soft tissue adjacent the knee and has at least one positioning feature adapted to move relative to the distal end of the femur as the femoral portion is adjusted, thus helping position a femoral prosthetic on the distal end of the femur. The sensor(s) may be adapted to sense pressure at medial and lateral sides of the knee, and relative pressures may be displayed as data on a visual display. Adjustments to the femoral member may be made to balance pressure at flexion and extension of the knee.

Dynamic knee balancer with pressure sensing

Dynamic knee balancing devices, systems and methods provide for enhanced total knee arthroplasty ('TKA') procedures. Devices generally include a stationary femoral member for removably attaching to a distal femur and an adjustable femoral member coupled with the stationary member for adjusting ligament tension of the knee. The adjustable femoral member includes at least one positioning feature for providing positional and/or orientation information for facilitating the TKA procedure. Additionally, the adjustable femoral member is movably couplable with a tibial member engaged with the proximal tibia to allow movement of the knee through a range of motion without removing the device from the joint space. When the adjustable femoral member is adjusted, the positional feature(s) move relative to the distal femur to provide positional information.

Dynamic knee balancer

A device for performing a surgical procedure on a knee comprises a femoral assembly comprising a stationary femoral member attachable to the distal femur, an adjustable femoral member movably coupled with the stationary member to adjust tension in at least one ligament of or adjacent the knee and an adjustment mechanism coupled to the assembly. The adjustable member includes at least one positioning feature that moves relative to the distal femur as the adjustable member is adjusted and identifies at least one position on the distal femur. The adjustable member is movably couplable with a tibial member engaged with a proximal tibia to allow the knee to be moved through a range of motion without removing the femoral and tibial members. The mechanism includes an actuator positioned proximate a medial or lateral portion of the adjustable member. The actuator is configured to adjust an opposite portion of the adjustable member.

Dynamic knee balancer with opposing adjustment mechanism

A micromechanical contact load force sensor is disclosed. The force sensor comprises an array of capacitive load cells on a substrate. The force sensor is able to sense high loads, on the order on 10 9 N/m 2 , and distribute the load over a suitable number of the cells of the array while minimizing crosstalk between adjacent cells. The force sensor is useful in biological and robotic applications.

Micromechanical contact load force sensor for sensing magnitude and distribution of loads and tool employing micromechanical contact load force sensor

Trenches which reduce or eliminate force and sensitivity associated with proof mass motion normal to the substrate as a result of voltage transients is disclosed. The trenches provide increased separation between interleaved comb electrodes and the substrate, and thereby also reduce the comb lift to drive ratio. The trenches are typically formed directly below the interleaved comb electrodes, but may also be formed below other suspended portions. Trench depth is from 6-10 microns and provides a comb electrode to substrate separation of approximately 8.5-12.5 microns.

Trenches to reduce charging effects and to control out-of-plane sensitivities in tuning fork gyroscopes and other sensors

A hybrid wafer gyroscope includes a combination of micro-machined components and traditional electromechanical components to form a miniature gyroscope having a high degree of stability. The gyroscope includes a rotor, gimbal, flexures, and stop cutouts micro-machined out of one or more layers of silicon, forming a unitary, planar, and disk-shaped rotor subassembly, which spins about a drive shaft.

Hybrid wafer gyroscope

MEMS and microelectronic devices and fabrication methods feature providing a first material including a glass, providing a second material having an elastic modulus greater than the elastic modulus of silicon, causing the second material to have a surface with a RMS surface roughness of greater than 0.001 μm and less than approximately 0.15 μm, contacting the surface of the second material to a surface of the first material, and applying a voltage between the first and second materials to cause an anodic bond to form.

Anodic bonding of silicon carbide to glass

Electrostatic capacitance measurements are used to detect chemical or biological analytes, or chemical interactions, with great sensitivity. A diaphragm is coated with a material capable of selectively interacting with an analyte of interest, and interaction of the analyte with the coating exerts stresses tangential to the diaphragm's surface. These stresses cause diaphragm displacements that are sensed as varying capacitance.

Stress-based electrostatic monitoring of chemical reactions and binding

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