R. S. Sparkes
University of California, Los Angeles
98 Papers
1.9K Citations
R. S. Sparkes is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Locus (genetics) & Gene. The author has an hindex of 31, co-authored 98 publications. Previous affiliations of R. S. Sparkes include UCLA Medical Center & University of California, Irvine.
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Papers
Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation
TL;DR: Since 5-azacytidine treatment results in hypomethylation of DNA, DNA methylation may be a mechanism of human X chromosome inactivation.
735
Confirmation of linkage between juvenile myoclonic epilepsy locus and the HLA region of chromosome 6.
TL;DR: This work confirms tight linkage of a JME locus to the HLA region of chromosome 6p, although at a larger recombination fraction than previously reported, and finds no significant evidence for linkage heterogeneity.
164
The human retinal degeneration slow (RDS) gene: chromosome assignment and structure of the mRNA.
Gabriel H. Travis,L Christerson,Patria E. Danielson,Ivana Klisak,R. S. Sparkes,L B Hahn,Thaddeus P. Dryja,J G Sutcliffe +7 more
TL;DR: The sequence of a full-length cDNA clone of the human RDS mRNA is presented, showing that in human retina there are two RDS transcripts of 3.0 and 5.5 kb and that the RDS gene is located on the proximal short arm of human chromosome 6.
153
•Journal Article
The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity.
TL;DR: There was little evidence for heterogeneity within any of the lod scores, under either the Predivided-Sample Test or the Admixture Test, and results continued to support linkage of IDDM with three chromosome 6 markers: HLA, BF, and GLO.
134
Origin of Human Bone Marrow Fibroblasts
TL;DR: The bone marrow fibroblast appears to be a mesenchymal cell, unrelated to haematopoietic stem cells, which is capable of in vitro proliferation after as much as 1000 rads of total body irradiation.
122