R. Coenen
University of Kiel
8 Papers
5 Citations
R. Coenen is an academic researcher from University of Kiel. The author has contributed to research in topics: Metachromatic leukodystrophy & Arylsulfatase A. The author has an hindex of 6, co-authored 8 publications.
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Papers
Phenotype of arylsulfatase A-deficient mice: Relationship to human metachromatic leukodystrophy
Barbara Hess,Paul Saftig,Dieter H. Hartmann,R. Coenen,Renate Lüllmann-Rauch,Hans H. Goebel,M Evers,Kurt von Figura,Rudi D'Hooge,Guy Nagels,Peter Paul De Deyn,Christoph Peters,Volkmar Gieselmann +12 more
TL;DR: In this article, arylsulfatase A-deficient mice were shown to exhibit a reduction of axonal cross-sectional area and an astrogliosis in 1-year-old mice; activation of microglia started at 1 year and was generalized at 2 years.
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Bone marrow stem cell-based gene transfer in a mouse model for metachromatic leukodystrophy: effects on visceral and nervous system disease manifestations
Ulrich Matzner,Dieter Hartmann,Renate Lüllmann-Rauch,R. Coenen,F. Rothert,Jan-Eric Månsson,P. Fredman,Rudi D'Hooge,P.P. De Deyn,Volkmar Gieselmann +9 more
TL;DR: The gene transfer did not delay the degeneration occurring in the acoustic ganglion of ASA-deficient animals, and the limited success of the therapy appears to be due to the requirement of unexpected high levels of ASA for correction of the metabolic defect.
86
Targeted Disruption of the Lysosomal α-Mannosidase Gene Results in Mice Resembling a Mild form of Human α-Mannosidosis
Sofia Stinchi,Renate Lüllmann-Rauch,Dieter Hartmann,R. Coenen,Tommaso Beccari,Aldo Orlacchio,Kurt von Figura,Paul Saftig +7 more
TL;DR: The mouse model will be a valuable tool for studying the pathogenesis of inherited alpha-mannosidosis and may help to evaluate therapeutic approaches for lysosomal storage diseases.
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Targeted disruption of the lysosomal α-mannosidase gene results in mice resembling a mild form of human α
Sofia Stinchi,Renate Lüllmann-Rauch,D ieter Hartmann,R. Coenen,Aldo Orlacchio,Kurt von Figura,Paul Saftig +6 more
- 01 Jan 1999
TL;DR: In this article, a mouse model was generated by targeted disruption of the gene for lysosomal α-mannosidase, which is involved in the degradation of asparagine-linked carbohydrate cores of glycoproteins.
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