Puttur D. Prasad
Georgia Regents University
180 Papers
1.2K Citations
Puttur D. Prasad is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Amino acid & Transporter. The author has an hindex of 69, co-authored 171 publications.
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Papers
Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
Nagendra Singh,Ashish Gurav,Sathish Sivaprakasam,Evan Brady,Ravi Padia,Huidong Shi,Muthusamy Thangaraju,Puttur D. Prasad,Santhakumar Manicassamy,David H. Munn,Jeffrey R. Lee,Stefan Offermanns,Vadivel Ganapathy +12 more
TL;DR: This paper showed that GPR109a signaling promoted anti-inflammatory properties in colonic macrophages and dendritic cells and enabled them to induce differentiation of Treg cells and IL-10-producing T cells.
1.9K
Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
TL;DR: This review focuses on three groups of nutrient transporters relevant to cancer: glucosetransporters, lactate transportters, and amino acid transporter, which are related to amino acid nutrition.
739
GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
Muthusamy Thangaraju,Gail Cresci,Kebin Liu,Sudha Ananth,Jaya P. Gnana-Prakasam,Darren D. Browning,John D. Mellinger,Sylvia B. Smith,Gregory J. Digby,Nevin A. Lambert,Puttur D. Prasad,Vadivel Ganapathy +11 more
TL;DR: It is shown that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon and suppresses nuclear factor-kappaB activation in normal and cancer colon cell lines as well as in normal mouse colon.
700
Human Intestinal H+/Peptide Cotransporter: CLONING, FUNCTIONAL EXPRESSION, AND CHROMOSOMAL LOCALIZATION
Rong Liang,You-Jun Fei,Puttur D. Prasad,Sammanda Ramamoorthy,Hong Han,Teresa L. Yang-Feng,Matthias A. Hediger,Vadivel Ganapathy,Frederick H. Leibach +8 more
TL;DR: Ch Chromosomal assignment studies with somatic cell hybrid analysis and in situ hybridization have located the gene encoding the cloned human H+/peptide cotransporter to chromosome 13 q33→q34.
519
Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis.
TL;DR: This review summarizes the protective roles of GPR41, GPR43 and GPR109A in dietary fibers-, gut microbiota- and SCFAs-mediated suppression of inflammation and carcinogenesis in gut and other organs.
472