Prettina Lazar
Gyeongsang National University
12 Papers
61 Citations
Prettina Lazar is an academic researcher from Gyeongsang National University. The author has contributed to research in topics: Docking (molecular) & Active site. The author has an hindex of 5, co-authored 12 publications.
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Papers
Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site.
Poornima Gajendrarao,Navaneethakrishnan Krishnamoorthy,Sugunadevi Sakkiah,Prettina Lazar,Keun Woo Lee +4 more
TL;DR: A homology model has been constructed for CYP4A22 and refined by molecular dynamics simulation, which yields structural knowledge, which would be helpful to design structure-based-drugs and functional experiments for the target protein.
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Pharmacophore Modeling, Virtual Screening and Molecular Docking Studies for Identification of New Inverse Agonists of Human Histamine H1 Receptor
Sundarapandian Thangapandian,Navaneethakrishnan Krishnamoorthy,Shalini John,Sugunadevi Sakkiah,Prettina Lazar,Yuno Lee,Keun Woo Lee +6 more
TL;DR: Three ligand-based three-dimensional pharmacophore models were built from a set of known HHR1 inverse agonists using HypoGen module of CATALYST software, finding that best model had a correlation coefficient of 0.854 for training set compounds and it was validated with an external test set with a high correlation value.
Structural origins for the loss of catalytic activities of bifunctional human LTA4H revealed through molecular dynamics simulations
TL;DR: Comparison of binding modes of substrates revealed the structural changes explaining the importance of R563 and K565 residues and the required alignment of substrate at the active site and the results of this study provide valuable information to be utilized in designing potent hLTA4H inhibitors as anti-inflammatory agents.
Molecular modeling study for interaction between Bacillus subtilis Obg and Nucleotides.
Yuno Lee,Woo Young Bang,Songmi Kim,Prettina Lazar,Chul Wook Kim,Jeong Dong Bahk,Keun Woo Lee +6 more
TL;DR: Four different molecular dynamics simulations were performed with/without the three different nucleotides and the possible binding conformation of the activated form of Obg with L13 was predicted, which is essential for the assembly with ribosome.
Molecular Dynamics Simulation Study for Ionic Strength Dependence of RNA-host factor Interaction in Staphylococcus aureus Hfq
TL;DR: The molecular dynamics simulations used to investigate the behavior of Staphylococcus aureus Hfq protein under two different ionic concentrations were compatible with the experimental data and this is the first theoretical report for the experimental study done in 1980 by Uhlenbeck group for the present system.