Philippe Lépicier
Université de Montréal
5 Papers
128 Citations
Philippe Lépicier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Cannabinoid receptor & Agonist. The author has an hindex of 5, co-authored 5 publications.
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Papers
Endocannabinoids protect the rat isolated heart against ischaemia.
TL;DR: Endocannabinoids exert a strong cardioprotective effect in a rat model of ischaemia–reperfusion that is mediated mainly through CB2‐receptors, and involves p38, ERK1/2, as well as PKC activation.
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Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart.
TL;DR: The data suggest that endogenous cannabinoids contribute to the endothelial protective effect of ischemic preconditioning in rat coronary arteries.
101
•Journal Article
The endogenous cardiac cannabinoid system: a new protective mechanism against myocardial ischemia
TL;DR: The ability of cannabinoids to reduce infarct size has been confirmed in vivo in anesthetized mice and rats and appears to be mediated through CB2-receptors, an important mechanism of protection against myocardial ischemia.
Signaling Pathways Involved in the Cardioprotective Effects of Cannabinoids
TL;DR: In this article, a review of the cardioprotective properties of cannabinoids, with an emphasis on the signaling pathways involved, is presented, which suggests that protein kinase C (PKC) and mitogen-activated protein kinases (MAPK) contribute to the protective effect ischemic preconditioning.
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Endothelial CB1-receptors limit infarct size through NO formation in rat isolated hearts
TL;DR: C(1)-receptors are present mainly on endothelial cells in the rat heart, and exert their effect through production of NO, in contrast, CB(2)-reCEPTors present on cardiomyocytes exert a cardioprotective effect independent of this endothelial factor.