Philipp Kron
University of Zurich
53 Papers
162 Citations
Philipp Kron is an academic researcher from University of Zurich. The author has contributed to research in topics: Medicine & Liver transplantation. The author has an hindex of 19, co-authored 43 publications. Previous affiliations of Philipp Kron include St James's University Hospital & University of Freiburg.
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Papers
First Comparison of Hypothermic Oxygenated PErfusion Versus Static Cold Storage of Human Donation After Cardiac Death Liver Transplants: An International-matched Case Analysis.
Philipp Dutkowski,Wojciech G. Polak,Paolo Muiesan,Andrea Schlegel,Cornelia J. Verhoeven,Irene Scalera,Michelle L. DeOliveira,Philipp Kron,Pierre-Alain Clavien +8 more
TL;DR: No graft failure due to intrahepatic cholangiopathy or nonfunction occurred in HOPE-treated livers, whereas 18% of unperfused DCD livers needed retransplantation.
Novel Real-time Prediction of Liver Graft Function During Hypothermic Oxygenated Machine Perfusion Before Liver Transplantation
Xavier Muller,Andrea Schlegel,Philipp Kron,Dilmurodjon Eshmuminov,Michael Würdinger,David Meierhofer,Pierre-Alain Clavien,Philipp Dutkowski +7 more
TL;DR: Assessment of flavin, a marker of mitochondrial complex I injury, in the perfusate provides a fast prediction of liver graft function and loss during ex situ MP before implantation, which may have high clinical relevance, as liver grafts from extended DBD or DCD donors carry considerable risks for recipients.
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Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation
Andrea Schlegel,Andrea Schlegel,Andrea Schlegel,Xavier Muller,Matteo Mueller,Anna Stepanova,Philipp Kron,Olivier de Rougemont,Paolo Muiesan,Paolo Muiesan,Pierre-Alain Clavien,Alexander Galkin,David Meierhofer,Philipp Dutkowski +13 more
TL;DR: The degree of mitochondrial injury during HOPE of human DCD livers, quantified by perfusate FMN and NADH, was predictive for liver function, suggesting hypothermic oxygenated perfusion improves mitochondrial function, and allows viability assessment of liver grafts before implantation.
166
Warm vs. cold perfusion techniques to rescue rodent liver grafts.
TL;DR: This is the first evidence that HOPE is superior to normothermic oxygenated perfusion in a clinically relevant model through modulation of the innate immunity and endothelial cell activation.
158
A multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation.
Andrea Schlegel,Matteo Mueller,Xavier Muller,Janina Eden,Rebecca Panconesi,Stefanie von Felten,Klaus Steigmiller,Richard X. Sousa Da Silva,Olivier de Rougemont,Jean-Yves Mabrut,Mickael Lesurtel,Miriam Cortes Cerisuelo,Nigel Heaton,Marc-Antoine Allard,René Adam,Diethard Monbaliu,Ina Jochmans,Martijn P D Haring,Robert J. Porte,Alessandro Parente,Paolo Muiesan,Philipp Kron,Magdy Attia,Dagmar Kollmann,Gabriela A. Berlakovich,Xavier Rogiers,Karin Petterson,Anne L Kranich,Stefanie Amberg,Beat Müllhaupt,Pierre-Alain Clavien,Philipp Dutkowski +31 more
TL;DR: In this article , a randomized controlled phase III trial was conducted to investigate the impact of hypothermic oxygenated perfusion (HOPE) on cumulative complications within a 12-month period after liver transplantation.
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