Philip M. Grant
Stanford University
67 Papers
347 Citations
Philip M. Grant is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 20, co-authored 63 publications.
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Papers
A single-cell atlas of the peripheral immune response in patients with severe COVID-19.
Aaron J. Wilk,Arjun Rustagi,Nancy Q. Zhao,Jonasel Roque,Giovanny J Martínez-Colón,Julia L. McKechnie,Geoffrey T. Ivison,Thanmayi Ranganath,Rosemary Vergara,Taylor Mi Hollis,Laura J. Simpson,Philip M. Grant,Aruna Subramanian,Albert J. Rogers,Catherine A. Blish +14 more
TL;DR: Single-cell transcriptomic analysis identifies changes in peripheral immune cells in seven hospitalized patients with COVID-19, including HLA class II downregulation, a heterogeneous interferon-stimulated gene signature and low pro-inflammatory cytokine gene expression in monocytes and lymphocytes.
Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.
Jennifer G. Wilson,Laura J. Simpson,Anne-Maud Ferreira,Arjun Rustagi,Jonasel Roque,Adijat Asuni,Thanmayi Ranganath,Philip M. Grant,Aruna Subramanian,Yael Rosenberg-Hasson,Holden T. Maecker,Susan Holmes,Joseph E. Levitt,Catherine A. Blish,Angela J. Rogers +14 more
TL;DR: Levels of inflammatory cytokines were not higher in severe COVID-19 patients than in moderate CO VID-19 or critically ill patients with ARDS or sepsis in this small cohort of patients.
Patients With Uncomplicated Coronavirus Disease 2019 (COVID-19) Have Long-Term Persistent Symptoms and Functional Impairment Similar to Patients with Severe COVID-19: A Cautionary Tale During a Global Pandemic.
Karen B. Jacobson,Mallika Rao,Hector Bonilla,Aruna Subramanian,Isabelle Hack,Martina Madrigal,Upinder Singh,Prasanna Jagannathan,Philip M. Grant +8 more
TL;DR: The authors assessed the prevalence of persistent functional impairment after coronavirus disease (COVID-19) and found significant persistent symptoms and functional impairment, even in non-hospitalized patients.
Risk Factor Analyses for Immune Reconstitution Inflammatory Syndrome in a Randomized Study of Early vs. Deferred ART during an Opportunistic Infection
Philip M. Grant,Lauren Komarow,Janet Andersen,Irini Sereti,Savita Pahwa,Michael M. Lederman,Joseph J. Eron,Ian Sanne,William G. Powderly,Evelyn Hogg,Carol Suckow,Andrew R. Zolopa +11 more
TL;DR: Concern about IRIS should not prompt deferral of ART in patients with advanced immunosuppression and non-tuberculous OIs, and the presence of a fungal infection, lower CD4+ T-cell counts and higher HIV RNA levels at baseline, and higher CD4- T- cell counts and lower HIVRNA levels on treatment are associated with IRIS.
Tenofovir and bone health
Philip M. Grant,Aoife G. Cotter +1 more
TL;DR: Given these findings, TDF-containing regimens may be gradually replaced with non-TDF containing regimens for the treatment of HIV infection, especially in those at higher risk for fragility fracture.
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