Petra Huehnchen
Humboldt University of Berlin
33 Papers
142 Citations
Petra Huehnchen is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 18 publications. Previous affiliations of Petra Huehnchen include Charité.
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Papers
Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation.
Petra Huehnchen,Timour Prozorovski,Philipp Klaissle,Anne Lesemann,Jens Ingwersen,Susanne A. Wolf,Andreas Kupsch,Orhan Aktas,Barbara Steiner +8 more
TL;DR: In this paper, the authors induced experimental autoimmune encephalomyelitis (EAE) by immunizing C57BL/6 mice with encephalitogenic myelin oligodendrocyte glycoprotein (MOG) p35-55.
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Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy
Petra Huehnchen,Christian Schinke,Nikola Bangemann,Adam D. Dordevic,Johannes Kern,Smilla K. Maierhof,Li Chyi Hew,Luca Nolte,Peter Körtvelyessy,Jens Christian Göpfert,Klemens Ruprecht,Christopher Somps,Jens-Uwe Blohmer,Jalid Sehouli,Matthias Endres,Wolfgang Boehmerle +15 more
TL;DR: Neurofilament light chain (NFL), a marker for neuroaxonal damage, is described as a translational surrogate marker for chemotherapy-induced polyneuropathy (CIPN), which may guide neurotoxic chemotherapy in the future.
Assessment of paclitaxel induced sensory polyneuropathy with "Catwalk" automated gait analysis in mice.
TL;DR: A novel mouse model is established for investigating the side effects of dose-dense paclitaxel therapy and the usefulness of automated gait analysis is underlined as an additional easy-to-use objective test for evaluating painful sensory polyneuropathy.
A novel preventive therapy for paclitaxel-induced cognitive deficits: preclinical evidence from C57BL/6 mice
TL;DR: A molecular pathomechanism is identified, which invokes PTX-induced cytotoxicity in NSC independent of cell cycle status, which could be pharmacologically inhibited with lithium without impairing paclitaxel’s tubulin-dependent cytostatic mode of action, enabling a potential translational clinical approach.
Cognitive impairment after cytotoxic chemotherapy
TL;DR: There is evidence that certain chemotherapy regimens cause PCCI more frequently than others as evidenced by 21 out of 23 studies in breast cancer patients (mainly FEC-T), whereas 2 out of 3 studies with colon cancer Patients (FOLFOX) did not observe significant changes.