Pedro León
University of Costa Rica
36 Papers
424 Citations
Pedro León is an academic researcher from University of Costa Rica. The author has contributed to research in topics: Population & Linkage disequilibrium. The author has an hindex of 19, co-authored 36 publications.
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Papers
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.
Ricardo Segurado,Sevilla D. Detera-Wadleigh,Douglas F. Levinson,Cathryn M. Lewis,Michael Gill,John I. Nurnberger,Nicholas John Craddock,J. Raymond DePaulo,Miron Baron,Elliot S. Gershon,Jenny Ekholm,Sven Cichon,Gustavo Turecki,Stephan Claes,John R. Kelsoe,Peter R. Schofield,Renee F. Badenhop,Renee F. Badenhop,Jean Morissette,Hilary Coon,Douglas Blackwood,L. Alison McInnes,Tatiana Foroud,Howard J. Edenberg,Theodore Reich,John P. Rice,Alison Goate,Melvin G. McInnis,Francis J. McMahon,Judith A. Badner,Lynn R. Goldin,Phil Bennett,Virginia L. Willour,Peter P. Zandi,Jianjun Liu,Conrad T. Gilliam,S H Juo,Wade H. Berrettini,Takeo Yoshikawa,Leena Peltonen,Leena Peltonen,Jouko Lönnqvist,Markus M. Nöthen,Johannes Schumacher,Christine Windemuth,Marcella Rietschel,Peter Propping,Wolfgang Maier,Martin Alda,Paul Grof,Guy A. Rouleau,Jurgen Del-Favero,Christine Van Broeckhoven,Julien Mendlewicz,Rolf Adolfsson,M. Anne Spence,Hermann Luebbert,L. J. Adams,Jennifer A. Donald,Philip B. Mitchell,Nicholas Barden,Eric Shink,William Byerley,Walter J. Muir,Peter M. Visscher,Stuart MacGregor,Hugh Gurling,Gursharan Kalsi,Andrew McQuillin,Michael Escamilla,Victor I. Reus,Pedro León,Nelson B. Freimer,Henrik Ewald,Torben A Kruse,Ole Mors,Uppala Radhakrishna,Jean-Louis Blouin,Stylianos E. Antonarakis,Nurten A. Akarsu +79 more
TL;DR: The present results for the very narrow model are promising but suggest that more and larger data sets are needed to support linkage, as well as suggest that linkage might be detected in certain populations or subsets of pedigrees.
Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica.
Luis G. Carvajal-Carmona,Luis G. Carvajal-Carmona,Roel A. Ophoff,Jaana Hartiala,Julio Molina,Pedro León,Jorge Ospina,Gabriel Bedoya,Nelson B. Freimer,Andres Ruiz-Linares,Andres Ruiz-Linares +10 more
TL;DR: The genetic similarity of the populations from Antioquia and the CVCR together with differences in LD between them should be exploitable for the identification and fine mapping of shared disease-related gene variants.
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The gene for an inherited form of deafness maps to chromosome 5q31
TL;DR: The gene for deafness in this kindred is mapped to chromosome 5q31, between the markers IL9 and GRL, by linkage analysis involving 99 informative relatives, and the family traces its ancestry to an affected founder born in Costa Rica in 1754.
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Use of linkage disequilibrium approaches to map genes for bipolar disorder in the Costa Rican population
Michael A. Escamilla,Mitzi Spesny,Victor I. Reus,Alvaro Gallegos,Luis Meza,Julio Molina,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Eduardo Fournier,Pedro León,Lauren B. Smith,Nelson B. Freimer +12 more
TL;DR: The population of the Central Valley of Costa Rica, which is descended from a small number of founders, should be suitable for LD mapping; this assertion is supported by reconstruction of extended haplotypes shared by distantly related individuals in this population suffering low-frequency hearing loss.
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Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: an initial screen for bipolar disorder loci on chromosome 18.
Michael A. Escamilla,L. Alison McInnes,Mitzi Spesny,Victor I. Reus,Norito Shimayoshi,David J. Tyler,Sandra Silva,Julio Molina,Alvaro Gallegos,Luis Meza,Maria L. Cruz,Steven L. Batki,Sophia Vinogradov,Thomas C. Neylan,Jasmine B. Nguyen,Eduardo Fournier,Carmen Araya,Samuel H. Barondes,Pedro León,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Lodewijk A. Sandkuijl,Nelson B. Freimer +22 more
TL;DR: Investigation of the feasibility of LD methods for genome screening using a sample of individuals affected with severe bipolar mood disorder (BP-I), from an isolated population of the Costa Rican central valley suggests that LD methods will be useful for mapping BP-I in a larger sample.
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