Aim In recent years, mobile applications have been developed for health education purposes The aim of this study was to determine whether Telegram-based virtual education versus in-person education can be effective for improving the quality of life in adolescents with moderate-to-severe asthma Design A single-blind randomized trial Methods Participants were 64 adolescents aged 12-19 years and were equally assigned randomly to group A (Telegram-based education) and group B (in-person education) during 22 June 2017-19 February 2018 The educational contents were similar for both groups The Mini Pediatric Asthma Quality of Life Questionnaire was used prior to intervention and 5 weeks postintervention for both groups of adolescents Results A statistically significant increase was observed in the quality of life in both groups (p < 001) After controlling the quality-of-life scores, there was no statistically significant difference between the groups in terms of the mean score for the quality of life and its domains (p < 05)

The effectiveness of telegram-based virtual education versus in-person education on the quality of life in adolescents with moderate-to-severe asthma: A pilot randomized controlled trial.

Improvement in Asthma Control in Asthmatic Children Following Asthma Camp Attendance

Five days after arrival in Nigeria, a 19-year-old female model called the Public Health Emergency Operation Centre with complaints of fever, cough, sore throat, catarrh, sneezing, and diarrhea. A nasopharyngeal swab Polymerase Chain Reaction (PCR) confirmed the diagnosis of COVID-19 on the 26th of March 2020 making her the very first coronavirus (COVID-19) case in Rivers State.  Following the diagnosis, the case was moved to the treatment center. Contact tracing of all possible contacts was conducted; one hundred and five contacts were located and asked to self-isolate for fourteen days. The patient had a relatively mild illness; she was treated and discharged home after two weeks when she had two consecutive negative PCR results.

First Case of Covid-19 in Rivers State: A Case Report on the Public Health Response

Introduction: Iron dyshomeostasis is implicated in the pathogenesis of asthma. Iron loading of airway cells &amp; gene expression of the iron uptake protein, transferrin receptor (TFR)1, positively correlates with type-2 (T2) cytokine responses, which are associated with features of disease. Methods: Anti-TFR1 (αTFR1) &amp; -IL-13 (αIL-13) were intranasally administered to a murine model of house dust mite (HDM)-induced asthma. TFR1+ cell numbers T2 gene expression &amp; lung function were assessed. Effects of IL-13 on TFR1 &amp; matrix metalloprotease (MMP)9 responses in bone marrow derived macrophages (BMDM) were investigated. Results: In HDM-induced asthma, αTFR1 reduces TFR1+ macrophages, but not TFR1+ epithelial cells. αTFR1 reduces airways inflammation, fibrosis, mucus secreting cells and airflow obstruction. αTFR1 has no effect on HDM-induced IL-13, but significantly suppresses MMP9 expression. IL-13 increases TFR1 expression in BMDMs&nbsp;&amp; αIL-13 reduces TFR1+&nbsp;macrophages in HDM-induced asthma. Significantly, the combination of IL-13 &amp;&nbsp;HDM increases MMP9 expression in BMDMs. Conclusion: We show a critical role for IL-13-mediated increases in TFR1 responses in the pathogenesis of asthma, highlighting the potential to target TFR1 in other diseases associated with altered iron metabolism such as COPD, idiopathic pulmonary fibrosis &amp; cystic fibrosis. Grant Support: University of Newcastle, HMRI

Relationship between interleukin-13 and transferrin receptor-1 responses in the pathogenesis of asthma

Introduction: Women are more affected by asthma than men, highlighting a role for female sex hormones in the pathogenesis of asthma. Asthmatic women on the oral contraceptive pill (OCP) have improved asthma symptoms and reduced asthma risk. An improved understanding of how female sex hormones and the OCP influence asthma outcomes may highlight new treatments for asthma. Methods: The effects of fluctuating hormone levels on metabolic responses were assessed in peripheral blood mononuclear cells (PBMCs). The effects of 17β-estradiol, depot-medroxyprogesterone (DMPA) and the OCP as well as inhibition of glucose-transporter 1 (GLUT-1) (via BAY876) or glycolysis (2DG), on key features of disease and metabolism-associated gene expression were assessed in murine models of experimental asthma. Results: Fluctuating sex hormone levels have differential effects on metabolism and TNF-α production in PBMCs. 17β-estradiol promotes features of severe experimental asthma and GLUT-1 expression, whilst DMPA and the OCP reduce disease and GLUT-1 expression in the lungs in experimental asthma. Inhibiting&nbsp;glucose metabolism achieved the same protective outcomes as DMPA and OCP treatment. Conclusions: This data demonstrates that female sex hormones alter asthma outcomes through the modulation of cellular metabolic pathways, highlighting the potential for harnessing these sex hormone mediated effects for the improved control of asthma in women.

Female sex hormones affect asthma severity by altering cellular metabolism in the airways

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Improvement in Asthma Control in Asthmatic Children Following Asthma Camp Attendance

First Case of Covid-19 in Rivers State: A Case Report on the Public Health Response

Relationship between interleukin-13 and transferrin receptor-1 responses in the pathogenesis of asthma

Female sex hormones affect asthma severity by altering cellular metabolism in the airways