Pankaj Kapahi
Buck Institute for Research on Aging
126 Papers
340 Citations
Pankaj Kapahi is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 46, co-authored 110 publications. Previous affiliations of Pankaj Kapahi include University of California, San Francisco & California Institute of Technology.
Chat about Author
Papers
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
Antonio Rossi,Pankaj Kapahi,Gioacchino Natoli,Takayuki Takahashi,Yi Chen,Michael Karin,M. Gabriella Santoro +6 more
TL;DR: A novel mechanism of anti-inflammatory activity which is based on the direct inhibition and modification of the IKKβ subunit of IKK is demonstrated, which explains how cyclopentenone prostaglandins function and can be used to improve the utility of COX2 inhibitors.
1.4K
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
1.3K
From discoveries in ageing research to therapeutics for healthy ageing
TL;DR: It is suggested that ageing research is entering a new era that has unique medical, commercial and societal implications, and that this era marks an inflection point in ageing research and for all biological research that affects the human healthspan.
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Remi-Martin Laberge,Yu Sun,Arturo V. Orjalo,Christopher K. Patil,Adam Freund,Lili Zhou,Samuel C. Curran,Albert R. Davalos,Kathleen A. Wilson-Edell,Su Liu,Chandani Limbad,Marco Demaria,Patrick Wai-Lun Li,Gene B. Hubbard,Yuji Ikeno,Martin A. Javors,Pierre Yves Desprez,Christopher C. Benz,Pankaj Kapahi,Peter S. Nelson,Judith Campisi +20 more
TL;DR: It is shown that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells, which might ameliorate age-related pathologies, including late-life cancer, by suppressing senescence-associated inflammation.
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.
Pankaj Kapahi,Di Chen,Aric N. Rogers,Subhash D. Katewa,Patrick Wai-Lun Li,Emma Lynn Thomas,Lutz Kockel +6 more
TL;DR: How modulating TOR signaling slows aging through downstream processes including mRNA translation, autophagy, endoplasmic reticulum (ER) stress signaling, stress responses, and metabolism is discussed.
672