肝・胆道疾患の Thrombelastography

Thrombelastography, although proven as a useful research tool has not been evaluated for its clinical utility against common coagulation laboratory tests. In this study we compare the thrombelastographic measurements with six common tests (the hematocrit, platelet count, fibrinogen, prothrombin time, activated thromboplastin time and fibrin split products). For such comparisons, two samples of subjects were selected, 141 normal volunteers and 121 patients with cancer. The data was subjected to various statistical techniques such as correlation, ANOVA, canonical and discriminant analysis to measure the extent of the correlations between the two sets of variables and their relative strength to detect blood clotting abnormalities. The results indicate that, although there is a strong relationship between the thrombelastographic variables and these common laboratory tests, the thrombelastographic variables contain additional information on the hemostatic process.

/pdf/comparison-of-thrombelastogrpahy-with-common-coagulation-27psjqnd5u.pdf

Comparison Of Thrombelastogrpahy With Common Coagulation Tests

From cell phones to treating cancer, EM energy plays a part in many of the innovations that we take for granted everyday. A basic force of nature, like nuclear energy or gravity, this energy can be harnessed and used, but still holds the potential to be harmful. The question remains, how safe are EM products? Bioeffects and Therapeutic Applicati

Bioeffects and Therapeutic Applications of Electromagnetic Energy

Cork oak acorns were chronically exposed to a 50-Hz, 15-μT electromagnetic field generated in a Helmholtz coil system for 13 weeks. The extremely low-frequency electromagnetic field increased the sprouting rate but did not modify the final percentage of germination and sprouting after a 13-week period. The significant increase in growth parameters of seedlings, such as main shoot length, axillary shoot formation, and fresh and dry weights of the emerged shoots, showed that electromagnetic stimulus was beneficial in increasing the biomass of Quercus suber seedlings.

Influence of chronic exposure to an electromagnetic field on germination and early growth of Quercus suber seeds: preliminary study.

Hematological changes in rats exposed to weak electromagnetic fields

An experimental model has been developed in which mice were chronically exposed to an ELF magnetic field, under controlled conditions, with the purpose of learning its effects on peripheral blood. The OF1 mice were continuously subjected for two generations to an external magnetic field of 15 μT (rms) and 50 Hz sinusoidal waves generated by a system of Helmholtz coils designed by our Institute (BIASC). The first generation of animals was exposed for a period of 17 weeks and the second generation, born in the field, was exposed for 14 weeks. The most usual hematological parameters of mothers (12 control and 12 exposed) and daughters (30 control and 30 exposed) were analyzed. A leukopenia in exposed daughters and significant variations of platelet levels between both experimental groups were noted. Besides a slight decrease in hematocrit, red blood cell levels and hemoglobin concentration have been observed in exposed mice. The greatest changes were found in animals of the second generation.

Effects of ELF Magnetic Fields on Hematological Parameters: An Experimental Model

OF1 mice were chronically exposed to a 50‐Hz sinusoidal East–West magnetic field 15 µT (rms), in order to evaluate the blood coagulation variations related to the effect of this nonionizing radiation. Mating and pregnancy of ancestors (first generation), and birth, lactation, and development of second‐generation female mice until adulthood took place in the experimental field. A global blood coagulation study of both control and exposed 14‐ to 15‐week‐old and 50‐ to 52‐week‐old, second‐generation females was carried out. Plasma calcium content was determined by atomic absorption spectrophotometry. Different steps of blood coagulation were studied by thromboelastography (TEG) in whole blood (WB), platelet‐rich plasma (PRP), and platelet‐poor plasma (PPP). A significant decrease (approximately 34.5%) of calcium concentration was detected with aging; however, no change was induced by medium‐term or long‐term exposure to extremely low frequency magnetic field (ELF‐MF). Medium‐term exposure could not be relate...

Effects of Extremely Low Frequency Magnetic Fields on Blood Coagulation in Mice: An Initial Study

OF1 mice were chronically exposed to a 50-Hz sinusoidal East–West magnetic field of 15 μT (rms), in order to make a peripheral blood study for a leukemogenic evaluation of this non-ionizing radiation. Mating and pregnancy of ancestors (first generation), and birth, lactation, and development of second-generation female mice until adulthood occurred in the experimental field. A hematological study of both control and exposed 14- to 15-week-old and 50- to 52-week-old, second-generation females was realized. Individual diagnosis of specimens and statistical analysis of results revealed a high incidence of blood leukoproliferative disorders in 14- to 15-week-old exposed females (relative risk [RR] = 3.00, p = 0.0033), despite the resistance of this strain of mice to developing malignancies under normal environmental conditions before they are 26 weeks old. Especially elevated incidences of lymphocytic (RR = 6.50, p = 0.0021) and chronic (RR = 4.00, p = 0.0153) leukemias were associated with medium-term (14–15...

A hematological study in mice for evaluation of leukemogenesis by extremely low frequency magnetic fields

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Effects of ELF Magnetic Fields on Hematological Parameters: An Experimental Model

Effects of Extremely Low Frequency Magnetic Fields on Blood Coagulation in Mice: An Initial Study

A hematological study in mice for evaluation of leukemogenesis by extremely low frequency magnetic fields