27 Papers
538 Citations
O Déas is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 10 publications.
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Papers
•Journal Article
Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes.
O Déas,Céline Dumont,Marion MacFarlane,Matthieu Rouleau,Chafika Hebib,Francis Harper,François Hirsch,Bernard Charpentier,Gerald M. Cohen,Anna Senik +9 more
TL;DR: In activated T cells, anti-CD2 and staurosporine induce a caspase-independent cell death pathway that exhibits prominent cytoplasmic features of apoptosis, however, casp enzyme activation is required for the proteolytic degradation of nuclear substrates such as PARP and lamins together with the DNA fragmentation and extreme chromatin condensation that occur in apoptotic cells.
178
Thiol-mediated inhibition of FAS and CD2 apoptotic signaling in activated human peripheral T cells.
O Déas,Céline Dumont,Bertrand Mollereau,Didier Métivier,C Pasquier,G Bernard-Pomier,François Hirsch,Bernard Charpentier,A Senik +8 more
TL;DR: The data suggest that GSH, the most abundant intracellular thiol antioxidant, may be important in counteracting Fas- and CD2-mediated apoptosis of T lymphocytes.
•Journal Article
Inhibitory effect of growth hormone on TNF-alpha secretion and nuclear factor-kappaB translocation in lipopolysaccharide-stimulated human monocytes.
A Haeffner,N. Thieblemont,O Déas,Ornella Marelli,Bernard Charpentier,A Senik,S D Wright,Nicole Haeffner-Cavaillon,François Hirsch +8 more
TL;DR: It is demonstrated that human THP-1 promonocytic cells, engineered by gene transfer to constitutively produce human growth hormone (hGH), secreted depressed amounts of TNF-alpha in response to challenge by LPS.
68
•Journal Article
CD2-induced apoptosis in activated human peripheral T cells: a Fas-independent pathway that requires early protein tyrosine phosphorylation.
Bertrand Mollereau,Marcel Deckert,O Déas,Frédéric Rieux-Laucat,François Hirsch,Alain Bernard,A Fischer,D H Lynch,Bernard Charpentier,F Le Deist,A Senik +10 more
TL;DR: The data suggest that CD2 is a Fas-independent cell death pathway that might contribute directly to the elimination of T cells expanding during an immune reaction.
62
Growth hormone prevents human monocytic cells from Fas-mediated apoptosis by up-regulating Bcl-2 expression
Astrid Haeffner,O Déas,Bertrand Mollereau,Jérôme Estaquier,Alexandre Mignon,Nicole Haeffner-Cavaillon,Bernard Charpentier,Anna Senik,François Hirsch +8 more
TL;DR: Evidence is provided that hGH mediates its protective effect through a Bcl‐2‐dependent pathway, clearly a crucial step in enhanced survival of monocytic cells exposed to Fas‐induced death.
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