Nicholas J. Lawrence
University of South Florida
66 Papers
594 Citations
Nicholas J. Lawrence is an academic researcher from University of South Florida. The author has contributed to research in topics: Protein tyrosine phosphatase & Cell growth. The author has an hindex of 26, co-authored 66 publications. Previous affiliations of Nicholas J. Lawrence include University of Manchester & University of Salford.
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Papers
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Liwei Chen,Shen Shu Sung,M.L. Richard Yip,Harshani R. Lawrence,Yuan Ren,Wayne C. Guida,Said M. Sebti,Nicholas J. Lawrence,Jie Wu +8 more
TL;DR: NSC-87877 is identified as the first PTP inhibitor capable of inhibiting Shp2 PTP in cell cultures without a detectable off-target effect and provides the first pharmacological evidence that Shp 2 mediates EGF-induced Erk1/2 MAP kinase activation.
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Abrogation of Heat Shock Protein 70 Induction as a Strategy to Increase Antileukemia Activity of Heat Shock Protein 90 Inhibitor 17-Allylamino-Demethoxy Geldanamycin
Fei Guo,Kathy Rocha,Purva Bali,Michael Pranpat,Warren Fiskus,Sandhya Boyapalle,Sandhya Kumaraswamy,Maria E. Balasis,Benjamin Greedy,E. Simon M. Armitage,Nicholas J. Lawrence,Kapil N. Bhalla +11 more
TL;DR: It is shown that ectopic overexpression of hsp70 in human acute myelogenous leukemia HL-60 cells (HL-60/hsp70) and high endogenous hSp70 levels in Bcr-Abl-expressing cultured CML-BC K562 cells confers resistance to 17-AAG-induced apoptosis, and abrogation of h Sp70 induction significantly enhances the antileukemia activity of 17- AAG.
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Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.
Harshani R. Lawrence,Roberta Pireddu,Liwei Chen,Yunting Luo,Shen Shu Sung,Ann Marie Szymanski,M. L Richard Yip,M. L Richard Yip,Wayne C. Guida,Said M. Sebti,Jie Wu,Nicholas J. Lawrence +11 more
TL;DR: Screening of the NCI diversity set of compounds has led to the identification of 5 (NSC-117199), which inhibits the protein tyrosine phosphatase (PTP) Shp2 with an IC50 of 47 microM.
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Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones.
Sylvie Ducki,Grant Mackenzie,Ben Greedy,Simon Armitage,Jérémie Fournier Dit Chabert,Elizabeth Bennett,James H. Nettles,James P. Snyder,Nicholas J. Lawrence,Nicholas J. Lawrence +9 more
TL;DR: The proposed models, in agreement with published biochemical data, show that combretastatin A4 binds to the colchicine site of beta-tubulin and that chalcones assume an orientation similar to that of podophyllotoxin.
83
Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly.
TL;DR: The combined 5D-QSAR model seems to reconcile the differences without compromise and represents a highly predictive model for compounds that bind to the colchicine-binding site of tubulin.
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