Nicholas Ceglia
Memorial Sloan Kettering Cancer Center
55 Papers
137 Citations
Nicholas Ceglia is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 16, co-authored 29 publications. Previous affiliations of Nicholas Ceglia include University of California, Irvine & University of British Columbia.
Chat about Author
Papers
Reprogramming of the circadian clock by nutritional challenge.
Kristin Eckel-Mahan,Vishal R. Patel,Sara de Mateo,Ricardo Orozco-Solis,Nicholas Ceglia,Saurabh Sahar,Sherry A. Dilag-Penilla,Kenneth A. Dyar,Pierre Baldi,Paolo Sassone-Corsi +9 more
TL;DR: It is demonstrated that it is specifically the nutritional challenge, and not the development of obesity, that causes the reprogramming of the clock and that the effects of the diet on the clock are reversible.
664
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
Luis A. Rojas,Zachary Sethna,Kevin C. Soares,Cristina Olcese,Erin V Patterson,Jayon Lihm,Nicholas Ceglia,Pablo Guasp,Rebecca Yu,A. Chandra,Tracey A. Waters,Jennifer Ruan,Masataka Amisaki,Abderezak Zebboudj,Zagaa Odgerel,Evelyna Derhovanessian,F.-J. Müller,Ina Rhee,Mahesh Yadav,Anton Dobrin,Michel Sadelain,Marta Łuksza,Noah A. Cohen,Laura H. Tang,O. Basturk,Mithat Gönen,Seth S. Katz,Andrew S. Epstein,Parisa Momtaz,Wungki Park,Ryan Sugarman,Anna M. Varghese,Elizabeth Won,Avni M. Desai,Alice C. Wei,Michael I. D’Angelica,T. Peter Kingham,Ira Mellman,Taha Merghoub,Jedd D. Wolchok,Ugur Sahin,Özlem Türeci,Benjamin Greenbaum,William R. Jarnagin,Jeffrey A. Drebin,Eileen M. O'Reilly,Vinod P. Balachandran +46 more
TL;DR: In this article , a phase I trial of adjuvant atezolizumab, autogene cevumeran, and a modified version of a four-drug chemotherapy regimen (mFOLFIRINOX) was conducted.
553
Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling.
Allen W. Zhang,Allen W. Zhang,Allen W. Zhang,Ciara H. O'Flanagan,Elizabeth A. Chavez,Jamie L. P. Lim,Jamie L. P. Lim,Nicholas Ceglia,Andrew McPherson,Matt Wiens,Pascale Walters,Tim Chan,Brittany Hewitson,Daniel Lai,Anja Mottok,Clémentine Sarkozy,Lauren Chong,Tomohiro Aoki,Xuehai Wang,Andrew P Weng,Jessica N. McAlpine,Samuel Aparicio,Samuel Aparicio,Christian Steidl,Kieran R Campbell,Kieran R Campbell,Sohrab P. Shah,Sohrab P. Shah,Sohrab P. Shah +28 more
TL;DR: A probabilistic model is presented that leverages prior knowledge of cell-type marker genes to annotate single-cell RNA sequencing data into predefined or de novo cell types, enabling automated annotation of cell types present in a tumor microenvironment.
366
Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks
Kenneth A. Dyar,Dominik Lutter,Anna Artati,Nicholas Ceglia,Yu Liu,Danny Armenta,Martin Jastroch,Sandra Schneider,Sara de Mateo,Marlene Cervantes,Serena Abbondante,Paola Tognini,Ricardo Orozco-Solis,Kenichiro Kinouchi,Christina Wang,Ronald S. Swerdloff,Seba Nadeef,Selma Masri,Pierre J. Magistretti,Valerio Orlando,Emiliana Borrelli,N. Henriette Uhlenhaut,Pierre Baldi,Jerzy Adamski,Matthias H. Tschöp,Kristin Eckel-Mahan,Kristin Eckel-Mahan,Paolo Sassone-Corsi +27 more
TL;DR: Overall, this work illustrates how dynamic metabolic relationships can be reconstructed across time and space and how integration of circadian metabolomics data from multiple tissues can improve the understanding of health and disease.
302
Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.
Selma Masri,Paul Rigor,Marlene Cervantes,Nicholas Ceglia,Carlos Sebastian,Cuiying Xiao,Manuel Roqueta-Rivera,Chu-Xia Deng,Timothy F. Osborne,Raul Mostoslavsky,Pierre Baldi,Paolo Sassone-Corsi +11 more
TL;DR: Comparison of the hepatic circadian transcriptomes reveals that SIRT6 and SIRT1 separately control transcriptional specificity and therefore define distinctly partitioned classes of circadian genes.
292