Nataliya Gorinski
Hannover Medical School
14 Papers
10 Citations
Nataliya Gorinski is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Palmitoylation & Biology. The author has an hindex of 8, co-authored 11 publications. Previous affiliations of Nataliya Gorinski include University of Göttingen & Hochschule Hannover.
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Papers
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
Luciana Berod,Christin Friedrich,Amrita Nandan,Jenny Freitag,Stefanie Hagemann,Kirsten Harmrolfs,Aline Sandouk,Christina Hesse,Carla N. Castro,Heike Bähre,Sarah K. Tschirner,Nataliya Gorinski,Melanie Gohmert,Christian T. Mayer,Jochen Huehn,Evgeni Ponimaskin,Wolf-Rainer Abraham,Rolf Müller,Matthias Lochner,Tim Sparwasser +19 more
TL;DR: Results indicate fundamental differences between TH17 cells and Treg cells regarding their dependency on ACC1-mediated de novo fatty acid synthesis, which might be exploited as a new strategy for metabolic immune modulation of TH17 cell–mediated inflammatory diseases.
Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking
Ute Renner,Andre Zeug,Andrew Woehler,Marcus Niebert,Alexander Dityatev,Galina Dityateva,Nataliya Gorinski,Daria Guseva,Dalia Abdel-Galil,Matthias Fröhlich,Frank Döring,Erhard Wischmeyer,Diethelm W. Richter,Erwin Neher,Evgeni Ponimaskin +14 more
TL;DR: The relative concentration of 5-HT1A–5-HT7 heterodimers and, consequently, their functional importance undergoes pronounced developmental changes during postnatal development are found.
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors.
Nataliya Gorinski,Monika Bijata,Sonal Prasad,Alexander Wirth,Dalia Abdel Galil,Andre Zeug,Daria V. Bazovkina,E. M. Kondaurova,Elizabeth A. Kulikova,Tatiana V. Ilchibaeva,Monika Zaręba-Kozioł,Francesco Papaleo,Diego Scheggia,Gaga Kochlamazashvili,Alexander Dityatev,Ian M. Smyth,Adam Krzystyniak,Jakub Wlodarczyk,Diethelm W. Richter,Tatyana Strekalova,Tatyana Strekalova,Stephan J. Sigrist,Claudia Bang,Lisa Hobuß,Jan Fiedler,Thomas Thum,Vladimir S. Naumenko,Ghanshyam N. Pandey,Evgeni Ponimaskin +28 more
TL;DR: It is shown that palmitoylation of 5-HT1AR by thePalmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder.
Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior.
Monika Bijata,Ewa Bączyńska,R. Müller,Krystian Bijata,Julia Masternak,Adam Krzystyniak,Bernadeta Szewczyk,Marcin Siwiec,Svitlana Antoniuk,Matylda Roszkowska,Izabela Figiel,Marta Magnowska,Krzysztof H. Olszyński,A. D. Wardak,Adam S. Hogendorf,Blazej Ruszczycki,Nataliya Gorinski,Josephine Labus,T. Stepien,Sylwia Tarka,Andrzej J. Bojarski,Krzysztof Tokarski,Robert K. Filipkowski,Evgeni Ponimaskin,Jakub Wlodarczyk +24 more
TL;DR: In this paper , a combination of behavioral, biochemical, and imaging methods was used to analyze 5-HT7R/MMP-9 signaling and dendritic spine plasticity in the hippocampus.
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DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels
Nataliya Gorinski,Daniel Wojciechowski,Daria Guseva,Dalia Abdel Galil,Franziska E. Mueller,Alexander Wirth,Stefan Thiemann,Andre Zeug,Silke Schmidt,Monika Zaręba-Kozioł,Jakub Wlodarczyk,Boris V. Skryabin,Silke Glage,Martin Fischer,Samer Al-Samir,Nicole Kerkenberg,Christa Hohoff,Weiqi Zhang,Volker Endeward,Evgeni Ponimaskin +19 more
TL;DR: The results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targetingDHHC7 activity may offer a potential therapeutic strategy for reducing hypertension.
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