N.H. Brooks
University of Manchester
20 Papers
96 Citations
N.H. Brooks is an academic researcher from University of Manchester. The author has contributed to research in topics: Transplantation & Heart failure. The author has an hindex of 10, co-authored 20 publications.
Chat about Author
Papers
Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate
Warwick B. Dunn,David Broadhurst,S. Deepak,Mamta H. Buch,Garry McDowell,Irena Spasic,David I. Ellis,N.H. Brooks,Douglas B. Kell,Ludwig Neyses +9 more
TL;DR: The findings demonstrate the power of data-driven metabolomics approaches to identify biomarkers of heart failure and not renal disease per se and 3 further new compounds were also excellent discriminators between patients and controls.
Has the publication of cardiac surgery outcome data been associated with changes in practice in northwest England: an analysis of 25 730 patients undergoing CABG surgery under 30 surgeons over eight years
Ben Bridgewater,Antony D. Grayson,N.H. Brooks,Geir Grotte,Brian M. Fabri,John Au,Tim Hooper,Mark Jones,Bruce E. Keogh +8 more
TL;DR: Publishing of cardiac surgery mortality data in the UK has been associated with decreased risk adjusted mortality on retrospective analysis of a large patient database and there is no evidence that fewer high risk patients are undergoing surgery because mortality rates are published.
Polymorphism of the transforming growth factor–beta 1 gene correlates with the development of coronary vasculopathy following cardiac transplantation
TL;DR: A correlation between a high-producing TGF-beta1 genotype and an earlier onset of cardiac-transplant coronary vasculopathy is demonstrated and gives an important insight into the pathophysiology of cardiac transplant vasculitis and suggests new treatment options.
70
Influence of tumor necrosis factor-α gene-308 polymorphism on the development of coronary vasculopathy after cardiac transplantation
TL;DR: Polymorphism at position -308 in the promoter region of the TNF-alpha gene fails to predict the development of cardiac transplant-related vasculopathy and cannot be used as a genetic risk marker.
28
Tumour necrosis factor alpha gene polymorphism: a predisposing factor to non-ischaemic myocardial dysfunction?
TL;DR: The TNF2 allele is overrepresented in patients with end stage non-ischaemic myocardial dysfunction, which may represent a genetic predisposition in a small subset of patients who could respond favourably to anti-TNF α treatment.
27