Monique Stoffels
National Institutes of Health
29 Papers
83 Citations
Monique Stoffels is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Periodic fever syndrome & Mevalonate kinase deficiency. The author has an hindex of 17, co-authored 29 publications. Previous affiliations of Monique Stoffels include Radboud University Nijmegen & Radboud University Nijmegen Medical Centre.
Chat about Author
Papers
OR11-002 - Mutations in MVK cause non-syndromic RP
Anna M. Siemiatkowska,Monique Stoffels,Kornelia Neveling,Anna Simon,P. M. van Hagen,A.I. den Hollander,F. P. M. Cremers,L. I. van den Born,R. W. J. Collin +8 more
TL;DR: Retinitis pigmentosa is a genetically heterogeneous retinal disease characterized by rod cell degeneration followed by cone cell death, which may ultimately lead to complete blindness.
1
THU0377 Efficacy, safety and pharmacokinetics of the anti-interleukin-1 beta antibody canakinumab in patients with schnitzler syndrome
H. D. de Koning,J. Schalkwijk,J. van der Ven-Jongekrijg,Monique Stoffels,J.W.M. van der Meer,Anna Simon +5 more
TL;DR: Data suggest that IL-1β plays a pivotal role in this disease and further study is needed to better define canakinumab treatment, while preliminary analysis of pharmacokinetics results are comparable to the results obtained in previous trials in CAPS patients.
MEFV mutations affecting pyrin amino acid 577 cause autosomal dominant autoinflammatory disease
Monique Stoffels,Agata Szperl,Anna Simon,Mihai G. Netea,Theo S. Plantinga,Marcel van Deuren,Sylvia Kamphuis,Helen J. Lachmann,Edwin Cuppen,Wigard P. Kloosterman,Joost Frenkel,Cleo C. van Diemen,Cisca Wijmenga,Marielle E. van Gijn,Jos W. M. van der Meer +14 more
TL;DR: Heterozygous mutations at amino acid position 577 of pyrin can induce an autosomal dominant autoinflammatory syndrome, which suggests that T577, located in front of the C-terminal B30.2/SPRY domain, is crucial for pyrIn function.
Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17.
Justin H. Fransen,Luuk B. Hilbrands,Jurjen M. Ruben,Monique Stoffels,Gosse J. Adema,Johan van der Vlag,Jo H. M. Berden +6 more
TL;DR: Apoptotic blebs, in contrast to apoptotic cell bodies, induce DC maturation, thereby providing DCs with increased Th17 cell stimulatory capacity in a murine setting, implying that apoptotic bleb-inducedDC maturation represents an important driving force in the autoimmune response in SLE.
The influence of concentration/meditation on autonomic nervous system activity and the innate immune response: a case study.
Matthijs Kox,Monique Stoffels,Sanne P. Smeekens,Nens van Alfen,Marc E. Gomes,Thijs M. H. Eijsvogels,Maria T. E. Hopman,Johannes G. van der Hoeven,Mihai G. Netea,Peter Pickkers +9 more
TL;DR: The concentration/meditation technique used by this particular individual seems to evoke a controlled stress response characterized by sympathetic nervous system activation and subsequent catecholamine/cortisol release, which seems to attenuate the innate immune response.