Michel Vignes
University of Montpellier
45 Papers
282 Citations
Michel Vignes is an academic researcher from University of Montpellier. The author has contributed to research in topics: Long-term potentiation & Metabotropic glutamate receptor. The author has an hindex of 17, co-authored 44 publications. Previous affiliations of Michel Vignes include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Papers
Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation.
Fabien Lanté,Johann Meunier,Janique Guiramand,Marie-Céleste de Jesus Ferreira,Gilles Cambonie,Gilles Cambonie,Rose Aimar,Catherine Cohen-Solal,Tangui Maurice,Michel Vignes,Gérard Barbanel +10 more
TL;DR: The results point to fetal hippocampal GSH as a major target of the detrimental effects of the in utero LPS challenge, suggesting that this drug might be clinically useful even after an immuno‐inflammatory episode.
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Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions.
Emmanuel Nivet,Michel Vignes,Stéphane D. Girard,Caroline Pierrisnard,Nathalie Baril,Arnaud Deveze,Jacques Magnan,Fabien Lanté,Michel Khrestchatisky,Francois Feron,François S. Roman +10 more
TL;DR: Data show that OE-MSCs can induce neurogenesis and contribute to restoration of hippocampal neuronal networks via trophic actions, and provide evidence that human olfactory tissue is a conceivable source of nervous system replacement cells.
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Kévin Baranger,Yannick Marchalant,Yannick Marchalant,Amandine E. Bonnet,Nadine Crouzin,Alex Carrete,Jean Michel Paumier,Nathalie A. Py,Anne Bernard,Charlotte Bauer,Eliane Charrat,Katrin Moschke,Mothoharu Seiki,Michel Vignes,Stefan F. Lichtenthaler,Stefan F. Lichtenthaler,Frédéric Checler,Michel Khrestchatisky,Santiago Rivera +18 more
TL;DR: MT5-MMP emerges as a new pro-amyloidogenic regulator of APP metabolism, whose deficiency alleviates amyloid pathology, neuroinflammation and cognitive decline, and a better preservation of the cortical neuronal network and synaptophysin levels in bigenic mice.
Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons.
Sophie Martin,Latifa Zekri,Alexandra Metz,Tangui Maurice,Karim Chebli,Michel Vignes,Jamal Tazi +6 more
TL;DR: Results show, for the first time, a requirement for G3BP1 in the control of neuronal plasticity and calcium homeostasis and further establish a direct link between SG formation and neurodegenerative diseases.
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Early, time-dependent disturbances of hippocampal synaptic transmission and plasticity after in utero immune challenge.
Marion Escobar,Nadine Crouzin,Mélanie Cavalier,Julie Quentin,Julien Roussel,Fabien Lanté,Aline Rideau Batista-Novais,Catherine Cohen-Solal,Marie-Céleste de Jesus Ferreira,Janique Guiramand,Gérard Barbanel,Michel Vignes +11 more
TL;DR: Aberrant forms of synaptic plasticity can be detected at early developmental stages after prenatal LPS challenge concomitant with a clear hypo-functioning of the NMDAr in the hippocampus, which might result in later-occurring brain dysfunctions.
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