Michael W. Johnson
University of California, Los Angeles
9 Papers
124 Citations
Michael W. Johnson is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: TSC1 & Tuberous sclerosis. The author has an hindex of 8, co-authored 9 publications.
Chat about Author
Papers
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho.
Richard F. Lamb,Christian Roy,Tom J. Diefenbach,Harry V. Vinters,Michael W. Johnson,Daniel G. Jay,Alan Hall +6 more
TL;DR: The data indicate that disruption of adhesion to the cell matrix through loss of hamartin may initiate the development of TSC hamartomas and that a Rho-mediated signalling pathway regulating cell adhesion may constitute a rate-limiting step in tumour formation.
348
Quantitative Trait Locus Analysis of Plasma Lipoprotein Levels in an Autoimmune Mouse Model Interactions Between Lipoprotein Metabolism, Autoimmune Disease, and Atherogenesis
TL;DR: The results support the concept that the high prevalence of coronary artery disease in systemic lupus erythematosus is due in part to a reduction of HDL cholesterol levels resulting from the autoimmune disease.
58
Cortical dysplasia, genetic abnormalities and neurocutaneous syndromes.
Harry V. Vinters,Sung Hye Park,Michael W. Johnson,Paul S. Mischel,Michael Catania,Christopher Kerfoot +5 more
TL;DR: The patterns and time course of hamartin/tuberin expression in normal brain, CD and TSC are discussed, and evidence that both proteins may influence cell growth and differentiation is discussed, specifically that they may represent growth suppressors.
40
Hamartin expression and interaction with tuberin in tumor cell lines and primary cultures.
Michael G. Catania,Michael W. Johnson,Linda M. Liau,Thomas J. Kremen,Jean deVellis,Harry V. Vinters +5 more
TL;DR: It is demonstrated that hamartin is widely expressed in human and rat cell lines and cultures, and demonstrate that hamartsin expression is not lost during the establishment of tumor cell lines or primary cultures.
24
Laser transmission through thin cirrus clouds
TL;DR: It is shown that transmission contributions produced by orders of scattering higher than 1 are small and can be neglected and the possibility of horizontal orientation of ice crystals can enhance transmission of laser beams in the aircraft-target geometry.