Michael L. Whitfield
Dartmouth College
135 Papers
345 Citations
Michael L. Whitfield is an academic researcher from Dartmouth College. The author has contributed to research in topics: Gene expression profiling & Biology. The author has an hindex of 47, co-authored 120 publications. Previous affiliations of Michael L. Whitfield include University of California, San Francisco & University of South Carolina.
Chat about Author
Papers
Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors
Michael L. Whitfield,Gavin Sherlock,Alok J. Saldanha,John I. Murray,Catherine A. Ball,Karen E. Alexander,John C. Matese,Charles M. Perou,Myra M. Hurt,Patrick O. Brown,David Botstein +10 more
TL;DR: The genome-wide program of gene expression during the cell division cycle in a human cancer cell line (HeLa) was characterized using cDNA microarrays to provide a comprehensive catalog of cell cycle regulated genes that can serve as a starting point for functional discovery.
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Tiffany Hung,Yulei Wang,Michael F. Lin,Michael F. Lin,Ashley K. Koegel,Yojiro Kotake,Yojiro Kotake,Gavin D. Grant,Hugo M. Horlings,Nilay Shah,Christopher B. Umbricht,Pei Wang,Yu Wang,Benjamin Kong,Anita Langerød,Anne Lise Børresen-Dale,Seung K. Kim,Marc J. van de Vijver,Saraswati Sukumar,Michael L. Whitfield,Manolis Kellis,Manolis Kellis,Yue Xiong,David J. Wong,Howard Y. Chang +24 more
TL;DR: In this article, an ultra-high-density array that tiles the promoters of 56 cell-cycle genes was used to interrogate 108 samples representing diverse perturbations, identifying 216 transcribed regions that encode putative lncRNAs, many with RT-PCR-validated periodic expression during the cell cycle.
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Tiffany Hung,Yulei Wang,Michael F. Lin,Michael F. Lin,Ashley K. Koegel,Yojiro Kotake,Yojiro Kotake,Gavin D. Grant,Hugo M. Horlings,Nilay Shah,Christopher B. Umbricht,Pei Wang,Yu Wang,Benjamin Kong,Anita Langerød,Anne Lise Børresen-Dale,Seung K. Kim,Marc J. van de Vijver,Saraswati Sukumar,Michael L. Whitfield,Manolis Kellis,Manolis Kellis,Yue Xiong,David J. Wong,Howard Y. Chang +24 more
- 01 Jun 2011
TL;DR: This work uses an ultrahigh-density array that tiles the promoters of 56 cell-cycle genes to interrogate 108 samples representing diverse perturbations and identifies 216 transcribed regions that encode putative lncRNAs, many with RT-PCR–validated periodic expression during the cell cycle.
960
Common markers of proliferation
TL;DR: Can the proliferation signature be used to improve the understanding of the cell cycle and cancer pathogenesis, as well as being used as a biomarker for cancer diagnosis and prognosis?
652
Shared and distinct mechanisms of fibrosis
Jörg H W Distler,Andrea-Hermina Györfi,Meera Ramanujam,Michael L. Whitfield,Melanie Königshoff,Melanie Königshoff,Robert Lafyatis +6 more
TL;DR: A number of core pathways and mechanisms of fibrosis, outlined in this Review, are shared across different tissues and might therefore present targets for general antifibrotic strategies and might enable the development of general antIFIBrotic compounds that are effective across different disease entities and organs.
486