Pincer complexes are becoming increasingly important for organometallic chemistry and organic synthesis. Since numerous applications for such catalysts have been developed in recent decades, this Minireview covers progress in their use as catalysts for (de)hydrogenation and transfer (de)hydrogenation reactions during the last four years. Aside from noble-metal-based pincer complexes, the corresponding base metal complexes are also highlighted and their applications summarized.

Pincer‐Type Complexes for Catalytic (De)Hydrogenation and Transfer (De)Hydrogenation Reactions: Recent Progress

Throughout the past two decades, the relationship between chirality and biological activity has become an area of vital importance to medicinal chemists in both the design and synthesis of novel small molecules. In this chapter, the definition of chirality and its biological implications are covered. The synthetic, chromatographic, and crystallization approaches to single isomer compounds are discussed with reference to the differing biological activities exhibited by stereoisomers.


Keywords:

chirality;
stereoisomers;
asymmetric;
resolution/separation;
drug;
binding;
potency;
metabolism

Chirality and Biological Activity

Synthesis and crystal structures of the first C2-symmetric bis-aldimine NCN–pincer complexes of platinum and palladium

The enantioselective construction of quaternary carbon centers is a marked challenge in asymmetric catalysis research. It is extremely difficult when a chiral catalyst can not distinguish the facial selectivity of the substrate through bond interactions. Here we realized an enantioselective Michael reaction of silyl ketene imines to 1-acrylpyrazoles using a chiral N,N'-dioxide-Co(II) complex. The protocol is highly efficient for the construction of nitrile-, aryl-, and dialkyl-bearing carbon centers and has been successful applied in the divergent synthesis of pharmaceuticals and natural products. The through-space dispersion interactions between unbound silyl ketene imines and the 1-acrylpyrazole-bonded catalyst play a key role in facilitating the reactivity and the enantioselectivity of this process.

Enantioselective Synthesis of Nitriles Containing a Quaternary Carbon Center by Michael Reactions of Silyl Ketene Imines with 1-Acrylpyrazoles.

Synthesis of [2,6-Bis(2-oxazolinyl)phenyl]palladium Complexes via the Ligand Introduction Route

Production of (R)-Aminoglutethimide: A New Route from 1-Chloro-4-nitrobenzene

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Production of (R)-Aminoglutethimide: A New Route from 1-Chloro-4-nitrobenzene