Michael J. Barratt
Washington University in St. Louis
45 Papers
47 Citations
Michael J. Barratt is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 15, co-authored 25 publications.
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Papers
Persistent gut microbiota immaturity in malnourished Bangladeshi children
Sathish Subramanian,Sayeeda Huq,Tanya Yatsunenko,Rashidul Haque,Mustafa Mahfuz,Mohammed Ashraful Alam,Amber Benezra,Amber Benezra,Joseph DeStefano,Martin Meier,Brian D. Muegge,Michael J. Barratt,Laura G. VanArendonk,Qunyuan Zhang,Michael A. Province,William A. Petri,Tahmeed Ahmed,Jeffrey I. Gordon +17 more
TL;DR: The results indicate that SAM is associated with significant relative microbiota immaturity that is only partially ameliorated following two widely used nutritional interventions.
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children
Laura V. Blanton,Mark R. Charbonneau,Tarek Salih,Michael J. Barratt,Siddarth Venkatesh,Olga Ilkaveya,Sathish Subramanian,Mark J. Manary,Indi Trehan,Josh M Jorgensen,Yue-Mei Fan,Bernard Henrissat,Semen A. Leyn,Dmitry A. Rodionov,Andrei L. Osterman,Kenneth Maleta,Christopher B. Newgard,Per Ashorn,Kathryn G. Dewey,Jeffrey I. Gordon +19 more
TL;DR: These preclinical findings provide evidence that gut microbiota immaturity is causally related to childhood undernutrition and reveal that specific beneficial microbes could potentially be exploited to resolve undernutrition syndromes.
672
Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition
Mark R. Charbonneau,David O'Donnell,Laura V. Blanton,Sarah M. Totten,Jasmine C.C. Davis,Michael J. Barratt,Jiye Cheng,Janaki L. Guruge,Michael Talcott,James R. Bain,Michael J. Muehlbauer,Olga Ilkayeva,Chao Wu,Tedd Struckmeyer,Daniela Barile,Charles Mangani,Josh M Jorgensen,Yue Mei Fan,Kenneth Maleta,Kathryn G. Dewey,Per Ashorn,Christopher B. Newgard,Carlito B. Lebrilla,David A. Mills,Jeffrey I. Gordon +24 more
TL;DR: Preclinical models indicate a causal, microbiota-dependent relationship between sialylated bovine milk oligosaccharides (S-BMO) and growth promotion in children with undernutrition.
586
Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
Jeanette L. Gehrig,Siddarth Venkatesh,Hao Wei Chang,Matthew C. Hibberd,Vanderlene L. Kung,Jiye Cheng,Robert Y. Chen,Sathish Subramanian,Carrie A. Cowardin,Martin Meier,David O'Donnell,Michael Talcott,Larry D. Spears,Clay F. Semenkovich,Bernard Henrissat,Bernard Henrissat,Richard J. Giannone,Robert L. Hettich,Olga Ilkayeva,Michael J. Muehlbauer,Christopher B. Newgard,Christopher S. Sawyer,Richard D. Head,Dmitry A. Rodionov,Dmitry A. Rodionov,Aleksandr A. Arzamasov,Aleksandr A. Arzamasov,Semen A. Leyn,Semen A. Leyn,Andrei L. Osterman,Iqbal Hossain,M Munirul Islam,Nuzhat Choudhury,Shafiqul Alam Sarker,Sayeeda Huq,Imteaz Mahmud,Ishita Mostafa,Mustafa Mahfuz,Michael J. Barratt,Tahmeed Ahmed,Jeffrey I. Gordon +40 more
TL;DR: Identifying ingredients in complementary foods, consumed during the transition from exclusive milk feeding to a fully weaned state, that increase the representation and expressed beneficial functions of growth-promoting bacterial taxa in the developing microbiota could provide an effective, affordable, culturally acceptable, and sustainable approach to treatment.
The effects of micronutrient deficiencies on bacterial species from the human gut microbiota.
Matthew C. Hibberd,Meng Wu,Dmitry A. Rodionov,Dmitry A. Rodionov,Xiaoqing Li,Jiye Cheng,Nicholas W. Griffin,Michael J. Barratt,Richard J. Giannone,Robert L. Hettich,Andrei L. Osterman,Jeffrey I. Gordon +11 more
TL;DR: The results suggest that micronutrient imbalances should be considered from the perspective of both the human host and the gut microbiota they possess, and that retinol treatment affected B. vulgatus fitness through the activity of the bacterial AcrAB-TolC efflux system.