Michael D. Moore
University of Oxford
12 Papers
53 Citations
Michael D. Moore is an academic researcher from University of Oxford. The author has contributed to research in topics: Aptamer & Biology. The author has an hindex of 10, co-authored 10 publications.
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Papers
Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages.
TL;DR: Using a CRISPR-Cas9 knockout strategy, it is shown that human iPSC-derived monocytes/macrophages develop in an MYB-independent, RUNX1-, and SPI1 (PU.1)-dependent fashion.
198
Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells
Amy E. Baxter,Amy E. Baxter,Rebecca A. Russell,Christopher J A Duncan,Michael D. Moore,Christian B. Willberg,José L. Pablos,Andrés Finzi,Daniel Kaufmann,Daniel Kaufmann,Christina Ochsenbauer,John C. Kappes,Fedde Groot,Quentin J. Sattentau +13 more
TL;DR: It is found that macrophages selectively capture and engulf HIV-1-infected CD4+ T cells leading to efficient macrophage infection, implying a mechanism distinct from conventional virological synapse formation.
168
RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation.
Julian Buchrieser,Julian Buchrieser,Maria Jose Oliva-Martin,Maria Jose Oliva-Martin,Michael D. Moore,Joshua C. D. Long,Sally A. Cowley,José A. Pérez-Simón,William James,José L. Venero,José L. Venero +10 more
TL;DR: Results reveal that RIPK1 has an important role in regulating the potent inflammatory pathways in authentic human macrophages that are poised to respond to external stimuli and might be a valid target in the development of novel therapies for chronic inflammatory diseases.
Protection of HIV Neutralizing Aptamers against Rectal and Vaginal Nucleases IMPLICATIONS FOR RNA-BASED THERAPEUTICS
Michael D. Moore,Jonathan Cookson,Veronica K. Coventry,Brian S. Sproat,L.K. Rabe,Ross D. Cranston,Ian McGowan,William James +7 more
TL;DR: A stable, antiviral RNA-based aptamer is derived that could form the basis of a pre-exposure microbicides or be a valuable addition to the current tenofovir-based microbicide candidate undergoing clinical trials.
41
The Productive Entry Pathway of HIV-1 in Macrophages Is Dependent on Endocytosis through Lipid Rafts Containing CD4
TL;DR: An effective genetic approach to manipulate the sub-cellular distribution of CD4 in macrophages is developed, and how this affects the HIV-1 entry pathway is investigated, which supports a model in which productive infection by HIV- 1 inmacrophages occurs via a CD4-raft-dependent endocytic uptake pathway.