7 Papers
11 Citations
Meng Lin is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Chemistry & Hybridization probe. The author has an hindex of 4, co-authored 7 publications.
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Papers
Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization.
Xin Chen,Na Liu,Liquan Liu,Wei Chen,Na Chen,Meng Lin,Jiaju Xu,Xing Zhou,Hongbo Wang,Meiping Zhao,Xianjin Xiao +10 more
TL;DR: A theoretical model of competitive DNA hybridisation is constructed to design DNA probes for optimisation-free mutation detection, and the 4-way Strand Exchange LEd Competitive DNA Testing (SELECT) system is invented, which breaks up the inverse correlation.
Branch migration based selective PCR for DNA mutation enrichment and detection.
TL;DR: A branch migration based PCR in which a branch migration blocker was introduced to selectively reduce the amplification efficiency of the wild-type target and enrich the mutant- type target and detect low-abundance mutations.
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Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules
TL;DR: The disclosed inhibition effect was coupled with the steric hindrance effect to establish a homogeneous assay for proteins and small molecules with ultra-high inhibition factors and sensitivity and constructed a complete thermodynamic model for it.
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Eliminating the secondary structure of targeting strands for enhancement of DNA probe based low-abundance point mutation detection.
TL;DR: An Open strand based strategy for eliminating the influence of secondary structures on the performance of nucleic acid probes is established and it is found that the improvement was higher when the secondary structure of the targeting strand was more complicated.
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Guiding-Strand-Controlled DNA Nucleases with Enhanced Specificity and Tunable Kinetics for DNA Mutation Detection.
Zhihao Ming,Wei Zhang,Meng Lin,Xiaofeng Tang,Na Chen,Na Liu,Xiaoyan Xin,Hongbo Wang,Wenpei Xiang,Xianjin Xiao +9 more
TL;DR: In this article, the authors developed guiding-strand-controlled nuclease systems and constructed theoretical kinetic models to explain their mechanisms of action, which displayed excellent agreement with the experimental results, making the kinetics highly predictable and tunable.
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