Melanie Clements
Imperial College London
33 Papers
137 Citations
Melanie Clements is an academic researcher from Imperial College London. The author has contributed to research in topics: Endoderm & Biology. The author has an hindex of 24, co-authored 28 publications. Previous affiliations of Melanie Clements include Medical Research Council & University College London.
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Papers
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
Colin Selman,Steven J. Lingard,Agharul I. Choudhury,Rachel L. Batterham,Marc Claret,Melanie Clements,Faruk Ramadani,Klaus Okkenhaug,Eugene Schuster,Eric Blanc,Matthew D.W. Piper,Hind Al-Qassab,John R. Speakman,Danielle Carmignac,Iain C. A. F. Robinson,Janet M. Thornton,David Gems,Linda Partridge,Dominic J. Withers +18 more
TL;DR: The results suggest that IRS1 signaling is an evolutionarily conserved pathway regulating mammalian life span and may be a point of intervention for therapies with the potential to delay age–related processes.
The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.
J.P. Martinez Barbera,Melanie Clements,Paul Q. Thomas,Tristan A. Rodriguez,D. Meloy,Dimitris Kioussis,Rosa S. P. Beddington +6 more
TL;DR: Results demonstrate that Hex function is essential in definitive endoderm for normal development of the forebrain, liver and thyroid gland and chimeric embryos composed of Hex(-/-) cells developing within a wild-type visceral endODerm show forebrain defects indicating that Hex is required in the definitiveendoderm.
The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration
Melanie Clements,Elizabeth Byrne,Luis F. Camarillo Guerrero,Anne-Laure Cattin,Leila Zakka,Azhaar Ashraf,Jemima J. Burden,Sanjay Khadayate,Alison C. Lloyd,Samuel Marguerat,Simona Parrinello +10 more
TL;DR: The wound microenvironment is a key determinant of Schwann cell identity, and it promotes nerve repair through integration of multiple concerted signals.
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The role of insulin receptor substrate 2 in hypothalamic and β cell function
Agharul I. Choudhury,Helen Heffron,Mark A. Smith,Hind Al-Qassab,Allison W. Xu,Colin Selman,Marcus Simmgen,Melanie Clements,Marc Claret,Gavin MacColl,David C. Bedford,Kazunari Hisadome,Ivan Diakonov,Vazira Moosajee,Jimmy D. Bell,John R. Speakman,Rachel L. Batterham,Gregory S. Barsh,Michael L.J. Ashford,Dominic J. Withers +19 more
TL;DR: A critical role for IRS2 is demonstrated in β cell and hypothalamic function and insights are provided into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis.
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm.
Sally L. Dunwoodie,Sally L. Dunwoodie,Melanie Clements,Duncan B. Sparrow,Xin Sa,Ronald A. Conlon,Rosa S. P. Beddington +6 more
TL;DR: It is demonstrated that Dll3(neo) and Dll 3(pu) are functionally equivalent alleles with respect to the skeletal dysplasia, and it is suggested that the three human DLL3 mutations associated with spondylocostal Dysplasia are also functionally equivalent to the Dll2(neO) null allele.