Matthias Mann
Max Planck Society
969 Papers
8.3K Citations
Matthias Mann is an academic researcher from Max Planck Society. The author has contributed to research in topics: Biology & Proteomics. The author has an hindex of 221, co-authored 887 publications. Previous affiliations of Matthias Mann include European Bioinformatics Institute & Wrocław Medical University.
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Papers
Revisiting biomarker discovery by plasma proteomics.
TL;DR: A “rectangular” plasma proteome profiling strategy is proposed, in which the proteome patterns of large cohorts are correlated with their phenotypes in health and disease.
SILAC Mouse for Quantitative Proteomics Uncovers Kindlin-3 as an Essential Factor for Red Blood Cell Function
Marcus Krüger,Markus Moser,Siegfried Ussar,Ingo Thievessen,Christian A. Luber,Francesca Forner,Sarah M. Schmidt,Sara Zanivan,Reinhard Fässler,Matthias Mann +9 more
TL;DR: The SILAC-mouse approach is a versatile tool by which to quantitatively compare proteomes from knockout mice and thereby determine protein functions under complex in vivo conditions.
750
Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology
Jürgen Cox,Matthias Mann +1 more
TL;DR: The principles of analysis and the areas of biology where proteomics can make unique contributions are described and the large-scale nature of proteomics data and its high accuracy pose special opportunities as well as challenges in systems biology that have been largely untapped so far.
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Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry
Edwin Lasonder,Edwin Lasonder,Yasushi Ishihama,Jens S. Andersen,Adriaan M. W. Vermunt,Arnab Pain,Robert Sauerwein,Wijnand Eling,Neil Hall,Andrew P. Waters,Hendrik G. Stunnenberg,Matthias Mann +11 more
TL;DR: A large-scale, high-accuracy mass spectrometric proteome analysis of selected stages of the human malaria parasite Plasmodium falciparum revealed 1,289 proteins that contain domains that indicate a role in cell–cell interactions, and therefore can be evaluated as potential components of a malaria vaccine formulation.
721
Improved resolution and very high sensitivity in MALDI TOF of matrix surfaces made by fast evaporation
TL;DR: A simple new sample preparation procedure in which matrix and sample handling are completely decoupled is described, which could be used for protein analysis in particular.
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