Matthew Gissel
University of Vermont
38 Papers
346 Citations
Matthew Gissel is an academic researcher from University of Vermont. The author has contributed to research in topics: Thrombin & Tissue factor. The author has an hindex of 18, co-authored 38 publications.
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Papers
The significance of circulating factor IXa in blood.
TL;DR: Concentrations of active coagulation enzymes circulating in vivo are significantly lower than can be predicted from the concentrations of their AP, and expected trace amounts of factor IXa can trigger thrombin generation in the absence of tissue factor.
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Factor XIa and tissue factor activity in patients with coronary artery disease.
Saulius Butenas,Anetta Undas,Matthew Gissel,Konstanty Szułdrzyński,Krzysztof Zmudka,Kenneth G. Mann +5 more
TL;DR: The majority of ACS and CAD-MI patients have circulating FXIa that correlates with markers of coagulation and inflammation, and this data indicates that inflammation and enhanced pro-coagulant activity are associated with the pathogenesis of atherosclerotic vascular disease.
Thrombin generation in acute coronary syndrome and stable coronary artery disease: dependence on plasma factor composition
Kathleen E. Brummel-Ziedins,Anetta Undas,Thomas Orfeo,Matthew Gissel,Saulius Butenas,Krzysztof Zmudka,Kenneth G. Mann +6 more
TL;DR: The differences between the thrombin generation profiles for each population were primarily dependent upon the collective contribution of AT, FII and FVIII.
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Thrombin generation and bleeding in haemophilia A
Kathleen E. Brummel-Ziedins,Matthew F. Whelihan,Matthew Gissel,Kenneth G. Mann,Georges E. Rivard +4 more
TL;DR: Empirical study in CTI‐inhibited whole blood shows that the MaxL of thrombin generation appears to correlate with the bleeding phenotype of haemophilia A.
Coagulation procofactor activation by factor XIa
TL;DR: FXIa activates both procofactors at plasma protein concentrations, and computational modeling suggests that procofactor activation during the preincubation phase of the APTT assay is critical to the performance of the assay.
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