Marlene Duarte
Instituto Português de Oncologia Francisco Gentil
4 Papers
Marlene Duarte is an academic researcher from Instituto Português de Oncologia Francisco Gentil. The author has contributed to research in topics: Cancer stem cell & Cell growth. The author has an hindex of 3, co-authored 4 publications.
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Papers
Clinical Impact of KRAS and GNAS Analysis Added to CEA and Cytology in Pancreatic Cystic Fluid Obtained by EUS-FNA.
Sandra Faias,Sandra Faias,Marlene Duarte,Cristina Albuquerque,Joao Silva,Ricardo Fonseca,Ricardo Fonseca,Ruben Roque,António Dias Pereira,Paula Chaves,Paula Chaves,Marília Cravo +11 more
TL;DR: In this cohort of patients with pancreatic cysts, KRAS and GNAS mutations had no significant diagnostic benefit in comparison with conventional testing.
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Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts
Sandra Faias,Marlene Duarte,Luísa Pereira,Paula Chaves,Marília Cravo,António Dias Pereira,Cristina Albuquerque +6 more
TL;DR: This is the first study to identify methylation changes in the GNAS locus, improving the diagnosis of malignant pancreatic cysts and suggesting a role in progression to PDAC.
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Polymethoxylated Flavones Target Cancer Stemness and Improve the Antiproliferative Effect of 5-Fluorouracil in a 3D Cell Model of Colorectal Cancer.
Carolina V. Pereira,Marlene Duarte,Patrícia Aparecida Barbosa Silva,Andreia Silva,Andreia Silva,Catarina M.M. Duarte,Alejandro Cifuentes,Virginia García-Cañas,Maria Rosário Bronze,Maria Rosário Bronze,Cristina Albuquerque,Ana Teresa Serra +11 more
TL;DR: All PMFs and OPE were shown to synergistically interact with 5-fluorouracil, improving the antiproliferative response of this drug.
Targeting colorectal cancer proliferation, stemness and metastatic potential using Brassicaceae extracts enriched in isothiocyanates: A 3D cell model-based study
Lucília Pebre Pereira,Patrícia Aparecida Barbosa Silva,Marlene Duarte,Liliana Rodrigues,Catarina M.M. Duarte,Cristina Albuquerque,Ana Teresa Serra +6 more
TL;DR: This research provides new insights on CRC therapy using ITC-enriched Brassicaceae extracts, specially watercress extract, to target CSCs and circulating tumor cells by impairing cell proliferation, ALDH1-mediated chemo-resistance, anoikis evasion, self-renewal and metastatic potential.