Marinus C. Lamers
Max Planck Society
51 Papers
920 Citations
Marinus C. Lamers is an academic researcher from Max Planck Society. The author has contributed to research in topics: B cell & Antigen. The author has an hindex of 29, co-authored 51 publications.
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Papers
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Manfred Kopf,Heinz Baumann,Giulia Freer,Marina A. Freudenberg,Marinus C. Lamers,Tadamitsu Kishimoto,Rolf M. Zinkernagel,Horst Bluethmann,Georges Köhler +8 more
TL;DR: It is concluded that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.
1.8K
Disruption of the murine IL-4 gene blocks Th2 cytokine responses
Manfred Kopf,G. Le Gros,Martin F. Bachmann,Marinus C. Lamers,Horst Bluethmann,Georges Köhler +5 more
TL;DR: It is concluded that IL-4 is required for the generation of the Th2-derived cytokines and that immune responses dependent on these cytokines are impaired.
1.2K
B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals
Florienne Loder,Bettina Mutschler,Robert J. Ray,Christopher J. Paige,Paschalis Sideras,Raul M. Torres,Marinus C. Lamers,Rita Carsetti +7 more
TL;DR: It is shown that selection into the mature pool is an active process and takes place in the spleen, and two populations of splenic B cells were identified as precursors for mature B cells.
Transitional B cells are the target of negative selection in the B cell compartment.
TL;DR: The functional and phenotypic division of IgMpos bone marrow B cells in three compartments not only allows to define the target population of physiological processes like negative selection, but will also be a helpful tool for an accurate description of possible developmental blocks in mutant mice.
388
The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein.
M. Terashima,Kwang-Myong Kim,Takahiro Adachi,Peter J. Nielsen,Michael Reth,Georges Köhler,Marinus C. Lamers +6 more
TL;DR: Three newly discovered intracellular proteins of 32, 37 and 41 kDa molecular mass are described, that are non‐covalently associated with mIgM, but not withmIgD, and could explain the different biological events elicited after engagement of each receptor.
255