Mariko Taga
Columbia University Medical Center
35 Papers
87 Citations
Mariko Taga is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Cognitive decline & Biology. The author has an hindex of 12, co-authored 23 publications. Previous affiliations of Mariko Taga include Brigham and Women's Hospital & Paris Diderot University.
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Papers
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
Marta Olah,Vilas Menon,Naomi Habib,Naomi Habib,Mariko Taga,Yiyi Ma,Christina J. Yung,Maria Cimpean,Anthony Khairallah,Guillermo Coronas-Samano,Roman Sankowski,Dominic Grün,Alexandra Kroshilina,Danielle Dionne,Rani A. Sarkis,Garth Rees Cosgrove,Jeffrey Helgager,Jeffrey A. Golden,Page B. Pennell,Marco Prinz,Jean Paul Vonsattel,Andrew F. Teich,Julie A. Schneider,David A. Bennett,Aviv Regev,Wassim Elyaman,Wassim Elyaman,Elizabeth M. Bradshaw,Elizabeth M. Bradshaw,Philip L. De Jager +29 more
TL;DR: The population structure of live microglia purified from human cerebral cortex samples obtained at autopsy and during neurosurgical procedures is investigated, and it is found that some subsets are enriched for disease-related genes and RNA signatures.
A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease.
Sara Mostafavi,Sara Mostafavi,Chris Gaiteri,Sarah E. Sullivan,Charles C. White,Shinya Tasaki,Jishu Xu,Mariko Taga,Mariko Taga,Hans-Ulrich Klein,Hans-Ulrich Klein,Ellis Patrick,Vitalina Komashko,Cristin McCabe,Robert V. Smith,Elizabeth M. Bradshaw,Elizabeth M. Bradshaw,David E. Root,Aviv Regev,Lei Yu,Lori B. Chibnik,Lori B. Chibnik,Julie A. Schneider,Tracy L. Young-Pearse,Tracy L. Young-Pearse,David A. Bennett,Philip L. De Jager,Philip L. De Jager +27 more
TL;DR: The construction and validation of a molecular network of the aging human frontal cortex is reported, constructed and validated from RNA sequence data from 478 individuals and identified genes that affect cognitive decline or neuropathology in Alzheimer's disease.
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Single cell RNA sequencing of human microglia uncovers a subset that is associated with Alzheimer’s disease: Molecular and cell biology: Inflammatory and microglia‐mediated mechanisms in AD
Marta Olah,Vilas Menon,Naomi Habib,Mariko Taga,Yiyi Ma,Anthony Khairallah,Christina J. Yung,Guillermo Coronas-Samano,Jean Paul Vonsattel,Andrew F. Teich,Julie A. Schneider,David A. Bennett,Aviv Regev,Philip L. De Jager +13 more
TL;DR: The extent of microglial heterogeneity in the aging human brain remains a central, yet poorly explored question in light of the development of therapies targeting this cell type in age related neurodegenerative diseases, such as Alzheimer’s disease.
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Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
Flora H. Duits,Pablo Martinez-Lage,Claire Paquet,Claire Paquet,Sebastiaan Engelborghs,Alberto Lleó,Lucrezia Hausner,José Luis Molinuevo,Erik Stomrud,Lucia Farotti,Inez H.G.B. Ramakers,Magda Tsolaki,Constance Skarsgard,Ragnar Åstrand,Anders Wallin,Martin Vyhnalek,Marie Holmber-Clausen,Orestes Vicente Forlenza,Laura Ghezzi,Martin Ingelsson,Erik Hoff,Gerwin Roks,Alexandre de Mendonça,Janne M. Papma,Andrea Izagirre,Mariko Taga,Mariko Taga,Hanne Struyfs,Daniel Alcolea,Lutz Frölich,Mircea Balasa,Lennart Minthon,Jos W. R. Twisk,Staffan Persson,Henrik Zetterberg,Henrik Zetterberg,Wiesje M. van der Flier,Charlotte E. Teunissen,Philip Scheltens,Kaj Blennow +39 more
TL;DR: This work investigated patient‐acceptance of LP, incidence of and risk factors for post‐LP complications in memory clinic populations and found no significant differences in patient acceptance or incidence of post-LP complications.
Microglial immunophenotype in dementia with Alzheimer's pathology.
Thais Minett,John Classey,Fiona E. Matthews,Marie Fahrenhold,Mariko Taga,Carol Brayne,Paul G. Ince,James A. R. Nicoll,James A. R. Nicoll,Delphine Boche,Mrc Cfas +10 more
TL;DR: The findings raise the possibility that in dementia with Alzheimer’s pathology, microglia lose motility (Iba-1) necessary to support neurons, and other microglial proteins, the role of which is clearance of damaged cellular material, are positively associated with Alzheimer's pathology and impaired cognitive function.