Molecular, clinical, and environmental toxicolog , Molecular, clinical, and environmental toxicolog , کتابخانه دیجیتال جندی شاپور اهواز

Molecular, Clinical and Environmental Toxicology

Fifty-seven pooled archived human serum samples were analyzed to assess the time trends as well as influence of age and gender on selected perfluorinated compounds (PFCs) in Norwegian residents. The study comprised determinations of 19 PFCs in serum samples pooled according to year of collection from 28 years in the period 1976 to 2007. A 9-fold increase in the serum concentrations of perfluorooctyl sulfonate, perfluorooctanoic acid, and perfluoroheptyl sulfonate was measured for men (40-50 years) from 1977 to the mid 1990s where the concentrations reached a plateau before starting to decrease around year 2000. A similar trend was also seen for perfluorohexyl sulfonate, perfluorononanoic acid, perfluorodecanoic acid, and perfluoroundecanoic acid, but no clear decline was observed for these PFCs in the recent years. No statistically significant difference was observed between the PFC levels in the male and female serum pools, though the statistical power is low due to few data points. For most PFCs, the concentrations in the human serum samples were found to increase with age in the pools from 2007, while the results for 1976, 1987, and 1998 were more varying. Several PFCs were significantly intercorrelated.

Time Trends and the Influence of Age and Gender on Serum Concentrations of Perfluorinated Compounds in Archived Human Samples

In 2000, 3M Company, the primary global manufacturer, announced a phase-out of perfluorooctanesulfonyl fluoride (POSF, C8F17SO2F)-based materials after perfluorooctanesulfonate (PFOS, C8F17SO3−) was reported in human populations and wildlife. The purpose of this study was to determine whether PFOS and other polyfluoroalkyl concentrations in plasma samples, collected in 2006 from six American Red Cross adult blood donor centers, have declined compared to nonpaired serum samples from the same locations in 2000−2001. For each location, 100 samples were obtained evenly distributed by age (20−69 years) and sex. Analytes measured, using tandem mass spectrometry, were PFOS, perfluorooctanoate (PFOA), perfluorohexanesulfonate (PFHxS), perfluorobutanesulfonate (PFBS), N-methyl perfluorooctanesulfonamidoacetate (Me-PFOSA-AcOH), and N-ethyl perfluorooctanesulfonamidoacetate (Et-PFOSA-AcOH). The geometric mean plasma concentrations were for PFOS 14.5 ng/mL (95% CI 13.9−15.2), PFOA 3.4 ng/mL (95% CI 3.3−3.6), and PFHx...

https://pubs.acs.org/doi/pdf/10.1021/es800071x

Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006.

Glyphosate in German adults – Time trend (2001 to 2015) of human exposure to a widely used herbicide

Environmental surveys, specimen bank and health related environmental monitoring in Germany.

The Environmental Specimen Bank for Human Tissues as part of the German Environmental Specimen Bank.

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The Environmental Specimen Bank for Human Tissues as part of the German Environmental Specimen Bank.