Aim This 6 month prospective multi-centre study evaluated the feasibility of performing myopic femtosecond lenticule extraction (FLEx) through a small incision using the small incision lenticule extraction (SMILE) procedure. Design Prospective, non-randomised clinical trial. Participants Ninety-one eyes of 48 patients with myopia with and without astigmatism completed the final 6 month follow-up. The patients9 mean age was 35.3 years. Their preoperative mean spherical equivalent (SE) was −4.75±1.56 D. Methods A refractive lenticule of intrastromal corneal tissue was cut utilising a prototype of the Carl Zeiss Meditec AG VisuMax femtosecond laser system. Simultaneously two opposite small ‘pocket’ incisions were created by the laser system. Thereafter, the lenticule was manually dissected with a spatula and removed through one of incisions using modified McPherson forceps. Main outcome measures Uncorrected visual acuity (UCVA) and best spectacle corrected visual acuity (BSCVA) after 6 months, objective and manifest refraction as well as slit-lamp examination, side effects and a questionnaire. Results Six months postoperatively the mean SE was −0.01 D±0.49 D. Most treated eyes (95.6%) were within ±1.0 D, and 80.2% were within ±0.5 D of intended correction. Of the eyes treated, 83.5% had an UCVA of 1.0 (20/20) or better, 53% remained unchanged, 32.3% gained one line, 3.3% gained two lines of BSCVA, 8.8% lost one line and 1.1% lost ≥2 lines of BSCVA. When answering a standardised questionnaire, 93.3% of patients were satisfied with the results obtained and would undergo the procedure again. Conclusion SMILE is a promising new flapless minimally invasive refractive procedure to correct myopia.

https://hal.archives-ouvertes.fr/hal-00567046/document

Small incision corneal refractive surgery using the small incision lenticule extraction (SMILE) procedure for the correction of myopia and myopic astigmatism: results of a 6 month prospective study

Purpose To report the clinical results of small incision lenticule extraction to correct refractive errors using a femtosecond laser to refine the femtosecond lenticule extraction technique. Setting Private laser center, Vadodara, India. Design Prospective clinical study. Methods The VisuMax femtosecond laser system was used to perform small incision lenticule extraction to treat refractive errors. The laser was used to cut a refractive lenticule intrastromally to correct myopia and myopic astigmatism. The lenticule was then extracted from the stroma through a 3.0 to 5.0 mm incision. Outcome measures were corrected distance visual acuity (CDVA), uncorrected distance visual acuity (UDVA), and manifest refraction during 6 months of follow-up. Corneal topography and ocular wavefront aberrations were also measured. Results The study enrolled 51 eyes of 41 patients. The mean spherical equivalent was −4.87 diopters (D) ± 2.16 (SD) preoperatively and +0.03 ± 0.30 D 6 months postoperatively. Refractive stability was achieved within 1 month ( P Conclusion All-in-one femtosecond refractive correction using a small incision technique was safe, predictable, and effective in treating myopia and myopic astigmatism. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned. Additional disclosure is found in the footnotes.

Results of small incision lenticule extraction: All-in-one femtosecond laser refractive surgery

Biomechanics and wound healing in the cornea

Some background as well as recent progress in the development of femtosecond lasers are discussed together with a brief outline of a few representative emergent applications in biology and medicine that are underpinned by access to such sources. We also provide a short summary of other contributions in this focus issue.

The development and application of femtosecond laser systems

Purpose To present initial clinical experience with small-incision lenticule extraction for the treatment of moderate to high myopia. Setting Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark. Design Prospective clinical study. Methods For small-incision lenticule extraction, an intrastromal lenticule was cut with a femtosecond laser and manually extracted without creation of a flap. Patients were treated and followed for 3 months. Only 1 randomly chosen eye of each patient was used in the statistical analyses. Results The study enrolled 144 patients. The mean preoperative spherical equivalent was −7.18 diopters (D) ± 1.57 (SD). Of eyes with emmetropia as target refraction, 40% had an uncorrected distance visual acuity of 0.1 logMAR or less 1 day after surgery; this increased to 73% at 3 months. The mean corrected distance visual acuity (CDVA) improved significantly from −0.01 (logMAR) preoperatively to −0.03 3 months postoperatively. None of the 127 eyes lost 2 lines or more of CDVA and 6 eyes lost 1 line of CDVA after 3 months. In contrast, 1 eye gained 2 lines and 24 eyes gained 1 line of CDVA. The achieved refraction was a mean of −0.09 ± 0.45 D from the attempted refraction. Of the eyes, 77% were within ±0.50 D and 95% were within ±1.00 D. Ninety-five percent of the patients would recommend the procedure to others. Conclusions The refractive predictability, safety, and patient satisfaction 3 months after small-incision lenticule extraction were high and comparable to results in previous studies of femtosecond laser–assisted techniques. Financial Disclosure Drs. Hjortdal and Asp received travel reimbursement from Carl Zeiss Meditec AG, Jena, Germany. No other author has a financial or proprietary interest in any material or method mentioned.

Small-incision lenticule extraction for moderate to high myopia: Predictability, safety, and patient satisfaction

Purpose To prospectively study the feasibility of femtosecond lenticule extraction (FLE), a new method of refractive correction. Setting Department of Ophthalmology, Philipps University of Marburg and Helios Clinic, Erfurt, Germany. Methods A flap and a lenticule of intrastromal corneal tissue were simultaneously cut with a VisuMax femtosecond laser system. Next, the lenticule was manually removed and the flap repositioned. The target refraction in all cases was −0.75 diopter (D). Results All 10 myopic eyes in the initial treatment group completed the final 6-month follow-up. The mean patient age was 39 years. The mean spherical equivalent (SE) was −4.73 ± 1.48 (SD) preoperatively and −0.33 ± 0.61 D 6 months postoperatively. Ninety percent of eyes were within ±1.00 D and 40% were within ±0.50 D of the intended correction. No eye lost 2 or more Snellen lines. Corneal topography showed large, prolate optical zones. Aberrometry showed no significant induction of higher-order aberrations. On a standardized questionnaire, all patients said they were very satisfied with the results. Conclusions Preliminary results indicate that FLE is a promising new corneal refractive procedure to correct myopia.

First efficacy and safety study of femtosecond lenticule extraction for the correction of myopia: six-month results.

Purpose To evaluate the visual outcome of refractive lenticule extraction in eyes with myopic astigmatism using the Visumax femtosecond laser. Setting Department of Ophthalmology, HELIOS Klinikum Erfurt, Erfurt, Germany. Design Nonrandomized clinical trials. Methods The data set encompassed treatments of sphere and astigmatism. Vector analysis was performed to study the astigmatic results at each follow-up visit at 1 week and 1, 3, and 6 months. Visual outcomes were analyzed for the 6-month follow-up period. Results The data evaluated was a complete set of refractive data of 182 treatments (87 left eyes, 95 right eyes). Efficacy, predictability, and safety with regard to astigmatic correction were comparable to the results with U.S. Food and Drug Administration–approved excimer lasers. At 6 months, the mean error ratio was 0.68 ± 0.75 (SD) and the mean correction ratio was 1.11 ± 0.69. There was slight astigmatic undercorrection (approximately 10%) over time. The residuum of the linear regression analysis of the predictability plot was approximately 0.4 diopter. Ninety-six percent of the eyes had a corrected distance visual acuity (CDVA) of 20/20 or better; no eye had a CDVA worse than 20/32. Conclusion Femtosecond refractive lenticule extraction is an effective procedure for correcting myopic astigmatism. Financial Disclosure Drs. Sluyterman v. L. and Russmann are employees of and Drs. Blum and Kunert are investigators for Carl Zeiss Meditec AG, Jena, Germany.

Vector analysis of myopic astigmatism corrected by femtosecond refractive lenticule extraction

A device and a method for the femtosecond laser surgery of tissue, especially in the vitreous humor of the eye. The device includes an ultrashort pulse laser with pulse widths in the range of approximately 10 fs-1 ps, especially approximately 300 fs, pulse energies in the range of approximately 5 nJ-5 μJ, especially approximately 1-2 μJ and pulse repetition rates of approximately 10 kHz-10 MHz, especially 500 kHz. The laser system is coupled to a scanner system which allows the spatial variation of the focus in three dimensions (x, y and z). In addition to the therapeutic laser/scanner optical system, the device includes a navigation system.

Device and method for vitreous humor surgery

Die Erfindung betrifft eine Vorrichtung und ein Verfahren zur Femtosekunden-Laserchirurgie von Gewebe, insbesondere im Glaskorper des Auges. Die Vorrichtung besteht aus einem Ultrakurzpulslaser mit Pulslangen im Bereich von ca. 10fs-1ps, insbesondere ca. 300fs, Pulsenergien im Bereich von ca. 5nJ-5μJ, insbesondere ca. 1-2 μJ und Pulsrepetitionsraten von ca. 10kHz- 10MHz, insbesondere 500 kHz. Das Lasersystem ist mit einem Scannersystem gekoppelt, das die raumliche Variation des Fokus in drei Dimensionen ermoglicht (x, y und z). Die Vorrichtung besteht neben diesem therapeutischen Laser-Scanner-Optik-System weiterhin aus einem damit gekoppelten Navigationssystem.

Vorrichtung und verfahren zur glaskörperchirurgie

Purpose To estimate the repeatability of biometric parameters obtained with a new swept-source biometer and to compare the agreement with that of partial coherence interferometry (PCI) and optical low-coherence reflectometry (OLCR). Setting Department of Ophthalmology, Helios Hospital Erfurt, Erfurt, Julius-Maximilians University, Wurzburg, and Philipps University, Marburg, Germany. Design Prospective comparative multicenter clinical study. Methods Biometry was taken with the use of 3 different biometers: the IOLMaster 700 swept-source biometer, the PCI-based IOLMaster 500, and the OCLR-based Lenstar LS 900. Axial length (AL), anterior chamber depth (ACD), and spherical equivalent (SE) were compared between swept-source and PCI biometry and central corneal thickness (CCT) and lens thickness (LT) between swept-source and OLCR biometry. The repeatability of swept-source biometry was evaluated on the basis of 3 measurements captured for each patient. Results One hundred twenty cataract eyes were included in the study. The mean difference between swept-source and PCI biometry for AL, ACD, and SE measurements was 4 μm ± 25 (SD), 17 ± 122 μm, and −0.001 ± 0.19 diopter (D), respectively. The mean difference between swept-source and OLCR biometry for LT and CCT measurements was 21 ± 122 μm and 0.15 ± 4.51 μm, respectively. Differences between swept-source biometry and the other devices distributed around zero without statistical significance. The standard deviation of repeatability for AL, ACD, LT, CCT, and SE was 8.8 μm, 9.8 μm, 2.3 μm, 19.5 μm, and 0.1 D, respectively. Conclusions Swept-source biometry showed high repeatability performance for all biometric parameters. The agreement of AL, ACD, and SE between swept-source and PCI biometry as well as that of LT and CCT between swept-source and OLCR biometry was excellent. It remains to be validated whether high repeatability shown by swept-source biometry will result in better postoperative refractive outcomes. Financial Disclosure Drs. Blum and Sekundo are members of the Scientific Advisory Board of Carl Zeiss Meditec AG. Drs. Peter and Buhren are employees of Carl Zeiss Meditec AG.

Repeatability and agreement in optical biometry of a new swept-source optical coherence tomography-based biometer versus partial coherence interferometry and optical low-coherence reflectometry.

Popular Tasks used by Researchers

How can I help with your research?

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

We encountered an error while loading the panel. Please try refreshing the page.

Something went wrong

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

Anyone with the link can view this chat. You can switch it back to private anytime.

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Marcus Blum

Author Tools

Chat about Author