Marco Giordano
University of Calabria
9 Papers
2 Citations
Marco Giordano is an academic researcher from University of Calabria. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Marco Giordano include Magna Græcia University.
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Papers
The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern.
Dina Bellizzi,Patrizia D'Aquila,Teresa Scafone,Marco Giordano,Vincenzo Riso,Andrea Riccio,Giuseppe Passarino +6 more
TL;DR: The data show that DNA methylation occurs in the mtDNA control region of mammals, not only at symmetrical CpG dinucleotides, typical of nuclear genome, but in a peculiar non-CpG pattern previously reported for plants and fungi.
Global DNA methylation levels are modulated by mitochondrial DNA variants
TL;DR: The findings indicate that mtDNA-specific interactions between mitochondria and the nucleus regulate epigenetic changes, possibly by affecting oxidative phosphorylation efficiency.
Age-and gender-related pattern of methylation in the MT-RNR1 gene.
Patrizia D'Aquila,Marco Giordano,Alberto Montesanto,Francesco De Rango,Giuseppe Passarino,Dina Bellizzi +5 more
TL;DR: The data further support the presence of methylation within human mitochondrial DNA and suggest that high levels ofmethylation of the MT-RNR1 site may reflect a condition of the cell or of the organism unfavorable to survival.
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The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians.
Alberto Montesanto,Valeria Latorre,Marco Giordano,Cinzia Martino,Filippo Domma,Giuseppe Passarino +5 more
TL;DR: The methodological approach used here allowed us to distinguish the effects of environmental and genetic factors on human longevity, and suggest that genetic factors in males have a higher impact than in females on attaining longevity.
ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.
Maria Mesuraca,Emanuela Chiarella,Stefania Scicchitano,Bruna Codispoti,Marco Giordano,Giovanna Nappo,Heather M. Bond,Giovanni Morrone +7 more
TL;DR: Two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 have been characterised as potent inhibitors of EBF1 and are emerging as potentially relevant contributors to the development of B-cell leukaemias.