Malcolm Maccoss
Schering-Plough
8 Papers
146 Citations
Malcolm Maccoss is an academic researcher from Schering-Plough. The author has contributed to research in topics: Viral replication & Septic arthritis. The author has an hindex of 4, co-authored 8 publications.
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Papers
Patent
Substituted piperidines that increase p53 activity and the uses thereof
Stephane L. Bogen,Yao Ma,Yaolin Wang,Brian R. Lahue,Latha G. Nair,Manami Shizuka,Matthew Ernst Voss,Margarita Kirova-Snover,Weidong Pan,Yuan Tian,Bheemashankar A. Kulkarni,Craig R. Gibeau,Yuan Liu,Giovanna Scapin,Diane Rindgen,Doll Ronald J,Timothy J. Guzi,Hicklin Danny J,Amin A. Nomeir,Cynthia Seidel-Dugan,Gerald W. Shipps,Malcolm Maccoss +21 more
- 27 Jun 2007
TL;DR: In this article, the present invention discloses novel compounds, as inhibitors of the HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds and methods of treatment, prevention, inhibition, of diseases associated with the diseases using such compounds or pharmaceutical compositions.
78
Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo
Zhong-Yue Sun,Theodros Asberom,Thomas A. Bara,Chad E. Bennett,Duane A. Burnett,Inhou Chu,John W. Clader,Mary Cohen-Williams,David Cole,Michael Czarniecki,James Durkin,Gioconda V. Gallo,William J. Greenlee,Hubert B. Josien,Xianhai Huang,Lynn A. Hyde,Nicholas Jones,Irina Kazakevich,Hongmei Li,Xiaoxiang Liu,Julie Lee,Malcolm Maccoss,Mihir B. Mandal,Troy Mccracken,Amin A. Nomeir,Robert Mazzola,Anandan Palani,Eric M. Parker,Dmitri A. Pissarnitski,Jun Qin,Lixin Song,Giuseppe Terracina,Monica L. Vicarel,Johannes H. Voigt,Ruo Xu,Lili Zhang,Qi Zhang,Zhiqiang Zhao,Xiaohong Zhu,Zhaoning Zhu +39 more
TL;DR: Cyclic hydroxyamidines were designed and validated as isosteric replacements of the amide functionality and applied in the identification of γ-secretase modulators leading to highly efficacious agents for reduction of central nervous system Aβ in various animal models.
52
Patent
Substituted amidine derivatives as inhibitors of cell adhesion
William K. Hagmann,Stephen E. deLaszlo,Theodore M. Kamenecka,Malcolm Maccoss +3 more
- 21 May 2001
TL;DR: In this paper, compounds of Formula I are formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimer's disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation and type I diabetes.
9
Patent
Compounds and methods for antiviral treatment
Malcolm Maccoss,F. George Njoroge,Amin A. Nomeir,Guangming Chen,Gary Mitchell Karp,William Joseph Lennox,Chunshi Li,Christie Morrill,Steven D. Paget,Hongyu Ren,Nanjing Zhang,Xiaoyan Zhang +11 more
- 05 Apr 2010
TL;DR: The present invention is directed to compounds of formula (I) and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
7
Patent
Composés deutérés en tant qu'inhibiteurs du virus de l'hépatite c (vhc)
Malcolm Maccoss,F. George Njoroge,Frank Bennett,Srikanth Venkatraman,Joseph A. Kozlowski,Wensheng Yu,Paul McNamara,Pernilla Royster +7 more
- 10 Dec 2009
TL;DR: In this paper, an invention concerne des compositions pharmaceutiques comprenant de tels composes ainsi que des methodes d'emplois desdits composes dans le traitement de troubles associes a la protease de VHC.