M. Grazia Ennas
University of Cagliari
9 Papers
67 Citations
M. Grazia Ennas is an academic researcher from University of Cagliari. The author has contributed to research in topics: Dopaminergic & Meth-. The author has an hindex of 8, co-authored 9 publications.
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Papers
PPARα Regulates Cholinergic-Driven Activity of Midbrain Dopamine Neurons via a Novel Mechanism Involving α7 Nicotinic Acetylcholine Receptors
Miriam Melis,Simona Scheggi,Gianfranca Carta,Camilla Madeddu,Salvatore Lecca,Antonio Luchicchi,Francesca Cadeddu,Roberto Frau,Liana Fattore,Paola Fadda,M. Grazia Ennas,M. Paola Castelli,Walter Fratta,Björn Schilström,Sebastiano Banni,M. Graziella De Montis,Marco Pistis +16 more
TL;DR: The results unveil important physiological functions of nAChR/PPARα signaling in dopamine neurons and how behavioral output can change after modifications of this signaling pathway and suggests PPARα as new therapeutic targets for disorders associated with unbalanced dopamine–acetylcholine systems.
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The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake
Sean C. Godar,Sean C. Godar,Marco Bortolato,M. Paola Castelli,Alberto Casti,Angelo Casu,Kevin Chen,M. Grazia Ennas,Simone Tambaro,Jean C. Shih,Jean C. Shih +10 more
TL;DR: Findings suggest that the behavioral deficits associated with low MAO-A activity may reflect developmental alterations of 5-HTT within5-HTergic neurons.
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6-Hydroxydopamine lesion in the ventral tegmental area fails to reduce extracellular dopamine in the cerebral cortex.
Paola Devoto,Giovanna Flore,Pierluigi Saba,M. Paola Castelli,A. Paola Piras,William Luesu,M. Cristina Viaggi,M. Grazia Ennas,Gian Luigi Gessa +8 more
TL;DR: The results strongly support the hypothesis that the majority of extracellular dopamine in the cortex, unlike that in the nucleus accumbens, originates from noradrenergic terminals.
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Δ9-tetrahydrocannabinol prevents methamphetamine-induced neurotoxicity.
M. Paola Castelli,Camilla Madeddu,Alberto Casti,Angelo Casu,P Casti,Maria Scherma,Liana Fattore,Paola Fadda,M. Grazia Ennas +8 more
TL;DR: Results indicate that Δ9-THC reduces METH-induced brain damage via inhibition of nNOS expression and astrocyte activation through CB1-dependent and independent mechanisms, respectively.
Methamphetamine neurotoxicity increases brain expression and alters behavioral functions of CB1 cannabinoid receptors
Marco Bortolato,Marco Bortolato,Roberto Frau,Roberto Frau,Valentina Bini,William Luesu,Roberta Loriga,Maria Collu,Gian Luigi Gessa,M. Grazia Ennas,M. Paola Castelli +10 more
TL;DR: It is suggested that METH neurotoxicity may alter the vulnerability to select behavioral effects of cannabis, by inducing distinct regional variations in the expression of CB₁ receptors.
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