Dapivirine-releasing vaginal rings produced by plastic freeforming additive manufacturing

Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications

Solid implantable devices for sustained drug delivery.

Advances in controlled release hormonal technologies for contraception: A review of existing devices, underlying mechanisms, and future directions.

Novel polyester-based thermoplastic elastomers for 3D-printed long-acting drug delivery applications.

Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings

Predicting powder feedability: A workflow for assessing the risk of flow stagnation and defining the operating space for different powder-feeder combinations.

Tribo-charging is often a root cause of mass flow deviations and powder adhesion during continuous feeding. Thus, it may critically impact product quality. In this study, we characterized the volumetric (split- and pre-blend) feeding behavior and process-induced charge of two direct compression grades of polyols, galenIQ™ 721 (G721) for isomalt and PEARLITOL^® 200SD (P200SD) for mannitol, under different processing conditions. The feeding mass flow range and variability, hopper end fill level, and powder adhesion were profiled. The feeding-induced tribo-charging was measured using a Faraday cup. Both materials were comprehensively characterized for relevant powder properties, and their tribo-charging was investigated for its dependence on particle size and relative humidity. During split-feeding experiments, G721 showed a comparable feeding performance to P200SD with lower tribo-charging and adhesion to the screw outlet of the feeder. Depending on the processing condition, the charge density of G721 ranged from -0.01 up to -0.39 nC/g, and for P200SD from -3.19 up to -5.99 nC/g. Rather than differences in the particle size distribution of the two materials, their distinct surface and structural characteristics were found as the main factors affecting their tribo-charging. The good feeding performance of both polyol grades was also maintained during pre-blend feeding, where reduced tribo-charging and adhesion propensity was observed for P200SD (decreasing from -5.27 to -0.17 nC/g under the same feeding settings). Here, it is proposed that the mitigation of tribo-charging occurs due to a particle size-driven mechanism. Graphical abstract

https://link.springer.com/content/pdf/10.1208/s12249-023-02552-5.pdf

Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of Isomalt and Mannitol Powders

Evaluating the flow-enhancing and antistatic properties of excipients in free and salt forms: A case study on stearic acid and magnesium stearate.

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Papers

Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings

Predicting powder feedability: A workflow for assessing the risk of flow stagnation and defining the operating space for different powder-feeder combinations.

Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of Isomalt and Mannitol Powders

Evaluating the flow-enhancing and antistatic properties of excipients in free and salt forms: A case study on stearic acid and magnesium stearate.